Non-targeted Cross-Sample Analysis with Comprehensive Two-Dimensional Gas Chromatography (GC×GC)
Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.
The goal of non-targeted cross-sample analysis is to discover salient chemical characteristics from multiple samples. Applications of non-targeted cross-sample analysis include sample classification, quality control, chemical fingerprinting and biomarker discovery. Non-targeted cross-sample analysis should distinguish and reliably characterize all chemical constituents in each sample, correctly match the corresponding features that characterize each constituent in different samples, and recognize the most significant characteristics or patterns between or among samples. Comprehensive two‑dimensional gas chromatography (GC×GC) is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis. GC×GC data is information-rich but is also large and complex, making the analytical tasks of extracting and matching features and then recognizing salient patterns challenging. This review surveys some of the varied approaches that researchers have applied to these difficult problems.
Traditional Chinese Medicine’s Effects on Liver Cancer Measured Using New UHPLC–QTOF-MS System
April 22nd 2024Scientists from Anhui University of Chinese Medicine in Hefei, China recently investigated the mechanisms behind what makes huachansu tablets, a type of traditional Chinese medicine (TCM), effective against liver cancer.
Inside the Laboratory: The Chromatography Laboratory at the University of Rouen
April 18th 2024In this edition of “Inside the Laboratory,” Pascal Cardinael and Valérie Agasse of the University of Rouen in Mont‑Saint-Aignan, France, discuss their laboratory’s work with miniaturizing gas chromatography (GC) columns and systems to improve on-site air analysis of volatile organic compounds (VOCs).
