Comprehensive two-dimensional gas chromatography is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis.
The goal of non-targeted cross-sample analysis is to discover salient chemical characteristics from multiple samples. Applications of non-targeted cross-sample analysis include sample classification, quality control, chemical fingerprinting and biomarker discovery. Non-targeted cross-sample analysis should distinguish and reliably characterize all chemical constituents in each sample, correctly match the corresponding features that characterize each constituent in different samples, and recognize the most significant characteristics or patterns between or among samples. Comprehensive two‑dimensional gas chromatography (GC×GC) is a powerful technology for separating complex samples and therefore is well suited for non-targeted analysis. GC×GC data is information-rich but is also large and complex, making the analytical tasks of extracting and matching features and then recognizing salient patterns challenging. This review surveys some of the varied approaches that researchers have applied to these difficult problems.
Targeted Blood Lipidomics of Colorectal Cancer: An HTC-18 Interview with Jef Focant
July 26th 2024At HTC-18 in Leuven, Executive Editor of LCGC International, Alasdair Matheson, spoke to Jef Focant from the University of Liege about his talk entitled, “Targeted Blood Lipidomics of Colorectal Cancer."
Carol Robinson Awarded 2024 Lifetime Achievement European Inventor Award
July 24th 2024Carol Robinson of the University of Oxford has received the European Inventor Award 2024 for Lifetime Achievement from the European Patent Office for her work bringing mass spectrometry to structural biology.