Optimizing the Analysis of Sugar Alcohol Excipients in Pharmaceutical Tablet Formulations Using Rezex Ion Exclusion HPLC Columns

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Sugar alcohols require unique methods for analysis by HPLC due to their high polarity and lack of a UV-absorbing chromophore. USP methods for these separations take advantage of ion exclusion HPLC techniques. In this note, several different separations of sugar alcohols were performed us­ing ion exclusion Rezex RPM and RCU HPLC columns.

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