PharmTech LCGC Sciex Webinar 11.10
|Articles|March 5, 2010

Oxidative Metabolism of Acetaminophen Using ROXY EC System

Acetaminophen (paracetamol; APAP; IUPAC: N-(4-hydroxyphenyl)acetamide) was chosen as model drug to investigate oxidative metabolism using the ROXY EC System dedicated for single component screening. Electrochemical conversion of the acetaminophen into reactive phase I metabolites and the NAPQI ? GSH phase II conjugate was successfully achieved.


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