
A novel SFC–QTOF-MS method accurately detected 10 drugs in oral fluid, matching LC–MS/MS in 83 DUID cases while reducing run time by 42% and organic solvent use by 81%.
In this month's instalment, the authors cover the topics of column-switching techniques and parallel chromatography for LC?MS?MS methods, and describe the time benefits that can be achieved using such systems. An example set-up is presented and the authors outline the various steps required to perform such analyses routinely.