LECO product profile
Variable Modulation Times (VMT) for Pegasus® 4D GCxGC-TOFMS optimisation is a unique feature designed and implemented by LECO. Traditional GCxGC uses a fixed modulation period and can result in an analytical compromise to the 1st dimension separation. The advantage of VMT enables the operator to specify at the click of a button their own and different modulation times throughout the GCxGC run time. Typically, applications taking advantage of GCxGC separations focus on matrix heavy &/or complex samples containing a broad range of analytes. In such complex mixtures, early eluting and more volatile analytes actually require shorter modulation times whilst later eluting analytes (high boilers) require much longer modulation times. Using the new LECO VMT programming style results in graduated Pegasus 4D® GCxGC-TOFMS chromatograms in the 2nd dimension and so preserves the valuable separation in the first dimension. This feature maximizes resolution in both the first and second dimensions and is compatible with LECO’s traditional LN2 and Consumable Free (CF) Pegasus 4D® GCxGC-TOFMS instruments.
The newly implemented features are built on a history of dedication and continuous development ensuring LECO continues to provide the gold standard of GCxGC instrumentation, the Pegasus 4D® GCxGC-TOFMS. For more information contact the LECO Separation Science team.
LECO European Technical Centre (ETC)
Marie-Bernays-Ring 31
41199 Mönchengladbach
Germany
Tel: +49 (0)2166 687 -104 or -107
Email: SepSci@leco.de
Web: www.leco.com
Measuring Procyanidin Concentration in Wines Using UHPLC
January 24th 2025Researchers from the University of Bordeaux (Villenave d'Ornon, France) report the development and validation of a rapid and quantitative analytical method measuring crown procyanidin concentration in red and white wines using ultra-high performance liquid chromatography (UHPLC) coupled with a ultra-high performance liquid chromatography (Q-TOF) mass spectrometer.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Testing Solutions for Metals and PFAS in Water
January 22nd 2025When it comes to water analysis, it can be challenging for labs to keep up with ever-changing testing regulations while also executing time-efficient, accurate, and risk-mitigating workflows. To ensure the safety of our water, there are a host of national and international regulators such as the US Environmental Protection Agency (EPA), World Health Organization (WHO), and the European Union (EU) that demand stringent testing methods for drinking water and wastewater. Those methods often call for fast implementation and lengthy processes, as well as high sensitivity and reliable instrumentation. This paper explains how your ICP-MS, ICP-OES, and LC-MS-MS workflows can be optimized for compliance with the latest requirements for water testing set by regulations like US EPA methods 200.8, 6010, 6020, and 537.1, along with ISO 17294-2. It will discuss the challenges faced by regulatory labs to meet requirements and present field-proven tips and tricks for simplified implementation and maximized uptime.