Resetting the standard in LC autosampling
Spark Holland product profile
Leading supplier, Spark Holland, has introduced the INTEGRITY™ autosampler – setting a new standard in sample care.
Packed with features, INTEGRITY™ has been designed for optimum care of precious samples. Innovative sample barcode identification (SBI™) technology ensures better control of sample tracking – 1D and 2D sample and sample tray identification codes can be read, filed and linked to sample assay results. It is even possible to record an image of the vial during sampling for visual verification of the injection and the sample vial afterwards. Combined with positive feedback motion control for the sample tray positioning, the risk of assigning results to the wrong sample is zero. Injection performance monitoring (IPM™) verifies that the injection itself has been performed correctly by pressure monitoring of the sample flow path during the entire injection cycle. INTEGRITY™ even checks for needle obstruction and missing vials before injecting a sample. Accurate sample temperature control is available from 4 - 40°C for the entire sample tray and sample processing space.
Spark’s concept of closed line sampling using pressure assisted sample aspiration (PASA™) directly from vial to valve has been specially developed for handling small samples, carryover and compatibility with UHPLC. A separate needle wash pump for better needle wash and faster injection cycles enable an entire injection-wash cycle in less than 20 seconds. Vial bottom detection facilitates efficient use of available sample volume and the microlitre-pick-up mode reduces sample loss to zero.
INTEGRITY™ is optimised for UHPLC systems up to 120MPa (18,000 PSI) and features advanced reagent addition and derivatisation, in addition to integrated online sample prep capabilities. The SparkLink™ software platform is available to provide comprehensive control of the extensive INTEGRITY™ capabilities. A special version of INTEGRITY™, the Integrity Plus doubles the standard 2 well plate capacity to accommodate 4 well plates or 216 standard 2ml vials.
Spark Holland will be showcasing the INTEGRITY™ at Pittcon (booth # 1161) or visit .
RAFA 2024: Giorgia Purcaro on Multidimensional GC for Mineral Oil Hydrocarbon Analysis
November 27th 2024Giorgia Purcaro from the University of Liège was interviewed at RAFA 2024 by LCGC International on the benefits of modern multidimensional GC methods to analyze mineral oil aromatic hydrocarbons (MOAH) and mineral oil saturated hydrocarbons (MOSH).
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
Identifying Antioxidative Properties in Berries with UHPLC-MS
Published: November 27th 2024 | Updated: November 27th 2024A recent study identified and quantified anthocyanin (which are known for their antioxidative properties and potential effectiveness against depression) in blueberries, blackberries, black mulberries, and cranberries using ultra high-pressure liquid chromatography (UHPLC) followed by in vivo evaluation of their antidepressant-like activities.
In Conversation with the EAS Award Winner for Outstanding Achievements in Mass Spectrometry
November 27th 2024As part of our EAS 2024 coverage, we recently interviewed Benjamin Garcia of the Washington University in St. Louis about his work and his being awarded the EAS Award for Outstanding Achievements in Mass Spectrometry.
