SEC-MALS Analysis of Biotherapeutics

Biozen dSEC-7 accurately resolves AAV serotypes 5, 8 and 9 monomer from aggregates in under 10 minutes with consistent results across different mobile phase conditions.

Determine the molecular weight of low abundant species with confident with the highly sensitive DAWN MALS detector and improved peak separation with Waters BEH Column.

Explore the optimization of AAV separation and the combined intrinsic fluorescence detection with SEC-MALS for low-concentration measurement.

In this application note, the charge variant characterisation of an IgG4-based mAb was performed using a BioPro IEX QF anion exchange column coupled to an MS detector.