News|Articles|January 21, 2026

Streamlining the SFC Method Development Workflow

This case study illustrates the streamlining of SFC method development using a mixture of six small molecule pharmaceuticals as a model sample, from automatic screening of columns and modifiers to design space evaluation for optimal conditions.


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Figure 2. Split injection used to measure triplicate test of MTBE, hexane, o-xylene, and 1-methylnaphthalene comparing different solvents (methanol, methylene chloride) and column insertion distances starting with 0.5 mm, 5.0 mm, 10.0 mm, 15 mm, and 20.0 mm. Methanol had the best performance at the 5.0 mm insertion distance and methylene chloride looked slightly better at the 0.5 mm. We would still recommend not going below the 5.0 mm manufacturer recommended insertion distance.
Revisiting insertion distance for methanol and methylene chloride in GC analysis and confirming that insertion depth strongly affects response and reproducibility.
Basel, Switzerland. Old town with red stone Munster cathedral on the Rhine river. © SCStock - stock.adobe.com
SFC Europe 2026 brings global experts to Basel for courses, scientific talks, workshops, and insights into greener separation technologies.
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