LCGC North America
There are many potential causes of reduced peak size in gas chromatography (GC), and an inexperienced GC user may not know where to begin the troubleshooting process. Here, we review potential causes for reduced peak size in GC systems.
We are frequently asked about issues with reduced peak size in gas chromatography (GC). There are so many potential causes for reduced peak size that an inexperienced GC user may not know where to begin in the troubleshooting process. Sensitivity problems can be grouped by way of their presentation within the chromatogram:
All peaks sizes (heights and or areas) decrease–retention times do not change.
As always, it’s best to start with the most obvious possible causes.
All peaks sizes (heights and areas) decrease. Retention times shift, no evidence of loss of efficiency (peak broadening)
All peaks sizes (heights and or areas) decrease–peaks are broadened, retention time shift may occur.
Tony Taylor is the Chief Science Officer of Arch Sciences Group and the Technical Director of CHROMacademy. Direct correspondence to: LCGCedit@mmhgroup.com.
Inside the Laboratory: The Gionfriddo Group at the University at Buffalo
March 28th 2024In this edition of “Inside the Laboratory,” Emanuela Gionfriddo, PhD, an associate professor of chemistry at the University at Buffalo, discusses her group’s current research endeavors, including using solid-phase microextraction (SPME) coupled to liquid chromatography (LC) and gas chromatography (GC) to further understand the chemical relationship between environmental exposure and disease and elucidate micropollutants fate in the environment and biological systems.
GC–MS Targeted Analysis of PFAS Helps Expand Knowledge of Toxicokinetic Data
March 26th 2024Limited toxicokinetic and toxicologic information is available about a diverse set of per- and polyfluoroalkyl substances (PFAS), but methods based on gas chromatography–tandem mass spectrometry (GC–MS/MS) can help unravel some of the mystery.
Best of the Week: What’s New in MS, 2024 Young Chemist Award Winner
March 22nd 2024This week, LCGC International published a variety of articles on the hottest topics in chromatography and beyond. Below, we’ve highlighted some of the most popular articles, according to our readers. Happy reading!