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There are many potential causes of reduced peak size in gas chromatography (GC), and an inexperienced GC user may not know where to begin the troubleshooting process. Here, we review potential causes for reduced peak size in GC systems.
We are frequently asked about issues with reduced peak size in gas chromatography (GC). There are so many potential causes for reduced peak size that an inexperienced GC user may not know where to begin in the troubleshooting process. Sensitivity problems can be grouped by way of their presentation within the chromatogram:
All peaks sizes (heights and or areas) decrease–retention times do not change.
As always, it’s best to start with the most obvious possible causes.
All peaks sizes (heights and areas) decrease. Retention times shift, no evidence of loss of efficiency (peak broadening)
All peaks sizes (heights and or areas) decrease–peaks are broadened, retention time shift may occur.
Tony Taylor is the Chief Science Officer of Arch Sciences Group and the Technical Director of CHROMacademy. Direct correspondence to: LCGCedit@mmhgroup.com.