Tuesday Afternoon Session Preview: New Developments in Ionization
The six presentations in this Tuesday afternoon session will examine various ionization techniques for mass spectrometry, including laserspray ionization, alternating current electrospray ionization, low-temperature plasma probe ambient ionization, electrode-assisted spray ionization, nano-electrospray ionization, and nanospray desorption electrospray ionization.
Room 155
The six presentations in this Tuesday afternoon session will examine various ionization techniques for mass spectrometry, including laserspray ionization, alternating current electrospray ionization, low-temperature plasma probe ambient ionization, electrode-assisted spray ionization, nano-electrospray ionization, and nanospray desorption electrospray ionization.
The first presentation in the session will be delivered by Charles N. McEwen of the University of the Sciences in PA (Philadelphia, Pennsylvania) and is titled “ESI-Like MALDI Ions: Laserspray Ionization, A Powerful New Technique for API Mass Spectrometers.” McEwen’s talk will discuss ionization improvements in laser ablation of MALDI matrices and more universal application of laserspray ionization.
McEwen’s presentation will be followed by a talk to be given by Nishant Chetwani of the University of Notre Dame (Mishawaka, Indiana) titled “Qualitative and Quantitative Behavior of AC Electrospray Ionization in Mass Spectrometry of Biomolecules.” Chetwani will discuss how alternating current electrospray ionization has been established as a soft ionization technique in biotechnology applications.
Joshua Wiley’s (Purdue University, West Lafayette, Indiana) presentation, titled “Low-Temperature Plasma Probe Ambient Ionization Source: Temporally and Spatially Resolved Investigations of Plasma–Sample Interactions,” will focus on characterizing processes that occur in the low-temperature plasma plume and at the plasma–sample interface.
Chung-Hsuan Chen of the Genomic Research Center (Taipei, Taiwan) will present “Electrode-Assisted Spray Ionization Mass Spectrometry.” Chen will discuss the development of a novel ambient ionization method and its application to studies of biological samples such as amino acids, peptides, proteins, and human fluids such as urine and blood.
The next presentation will be given by R. Brent Dixon of the Pacific Northwest National Laboratory (Richland, Washington) and will be titled “Exploration and Developments in Nano-Electrospray Ionization Sources Operating at Atmospheric and Sub-Atmospheric Pressure.” In this presentation, Dixon will talk about the implementation of microfabricated electrospray emitter arrays and operation of the electrospray at reduced pressures for improving ion transmission efficiency.
The final presentation in the session will be delivered by Patrick Roach, also of the Pacific Northwest National Laboratory. His presentation, titled “Nanospray Desorption Electrospray Ionization Mass Spectrometry” will cover the first demonstration of an ambient surface-ionization technique that separates desorption from ionization and provides improved control of ion formation.
Measuring Procyanidin Concentration in Wines Using UHPLC
January 24th 2025Researchers from the University of Bordeaux (Villenave d'Ornon, France) report the development and validation of a rapid and quantitative analytical method measuring crown procyanidin concentration in red and white wines using ultra-high performance liquid chromatography (UHPLC) coupled with a ultra-high performance liquid chromatography (Q-TOF) mass spectrometer.
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Testing Solutions for Metals and PFAS in Water
January 22nd 2025When it comes to water analysis, it can be challenging for labs to keep up with ever-changing testing regulations while also executing time-efficient, accurate, and risk-mitigating workflows. To ensure the safety of our water, there are a host of national and international regulators such as the US Environmental Protection Agency (EPA), World Health Organization (WHO), and the European Union (EU) that demand stringent testing methods for drinking water and wastewater. Those methods often call for fast implementation and lengthy processes, as well as high sensitivity and reliable instrumentation. This paper explains how your ICP-MS, ICP-OES, and LC-MS-MS workflows can be optimized for compliance with the latest requirements for water testing set by regulations like US EPA methods 200.8, 6010, 6020, and 537.1, along with ISO 17294-2. It will discuss the challenges faced by regulatory labs to meet requirements and present field-proven tips and tricks for simplified implementation and maximized uptime.
