Tuesday Morning Parallel Session on Microscale Separations
Today from 9:00 to 10:30 am, there will be a parallel session titled “Microscale Separations,” which will include four talks from experts in the field. This session will be presided over by Takuya Kubo of Kyoto University and Sebastian Piendl of the University of Leipzig. This session will take place in Ballroom B.
The first keynote lecture starts promptly at 9:00 am and is titled “Capillary LC at 35,000 PSI and Beyond for Complex Mixture Analysis.” This lecture will be delivered by Robert Kennedy of the University of Michigan.
Next, at 9:30 am, the second keynote lecture in this session will take place. The title of this lecture is “Miniaturized LC Separations for Single-Cell Proteomics.” Ryan Kelly from Brigham Young University will deliver this lecture.
Then, at 10:00 am, a talk titled “Nanoscale Separations to Enable Bottom-up, Top-down, and Native Proteomic Profiling of ng- and Sub-ng-level Samples” will take place. Alexander R. Ivanov of Northeastern University will deliver this talk. Michael Gregus, Anne-Lise Marie, Kendall Johnson, Yunfan Gao, and Somak Ray of Northeastern University are the co-authors of this paper.
Finally, from 10:15–10:30 am, a talk titled “High Aspect Ratio Pillar Array Columns for Deep Proteome Profiling at Moderate LC Pump Pressures,” will take place. Paul Jacobs of Thermo Fisher Scientific will conclude this session. Jeff Op de Beeck, Natalie Van Landuyt, David Bergen, Romain Huguet, Joshua Silveira, Xuefei Sun, and Brandon Robson, all with Thermo Fisher Scientific, are the co-authors of this paper.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.
Metabolomics Analysis of Low Birth-Weight Infants Using UHPLC-MS/MS Following Lipid Emulsion
January 10th 2025A recent study aimed to directly compare the changes in serum metabolites among very low birth-rate (VLBW) infants following the administration of the soybean oil-based lipid emulsion and soybean oil, medium-chain triglycerides, olive oil, and fish oil (SMOF) lipid emulsion using untargeted metabolomics techniques.
Analyzing New Drug Modalities: An ISC 2024 Interview with Kelly Zhang
January 10th 2025At ISC 2024 in Liverpool, United Kingdom, LCGC International interviewed Kelly Zhang of Genentech about her work analyzing new drug modalities, such as mRNA, oligonucleotides, peptides, and cell and gene therapies.
