This article describes a strategy for increasing the sensitivity of the bioanalytical assays through manipulation of the pH of the mobile phase and the use of column technology that is robust to a wide pH range.
High-sensitivity bioanalytical assays are critical for the full elucidation of pharmacokinetic profiles of drugs at very low exposure; and are also required when sample volume is limited as in the case of paediatric samples or low volume samples from small rodent studies. The use of LC–MS–MS for bioanalytical assays confers a high level of specificity and sensitivity for the analyte of interest but when the limits of a mass spectrometer are met, other means of increasing the sensitivity of an assay must be investigated. This article describes a strategy for increasing the sensitivity of the bioanalytical assays through manipulation of the pH of the mobile phase and the use of column technology that is robust to a wide pH range.
Targeted Blood Lipidomics of Colorectal Cancer: An HTC-18 Interview with Jef Focant
July 26th 2024At HTC-18 in Leuven, Executive Editor of LCGC International, Alasdair Matheson, spoke to Jef Focant from the University of Liege about his talk entitled, “Targeted Blood Lipidomics of Colorectal Cancer."
Carol Robinson Awarded 2024 Lifetime Achievement European Inventor Award
July 24th 2024Carol Robinson of the University of Oxford has received the European Inventor Award 2024 for Lifetime Achievement from the European Patent Office for her work bringing mass spectrometry to structural biology.