LCGC Europe
An excerpt from LCGC’s professional development platform, CHROMacademy.com
An excerpt from LCGC’s professional development platform, CHROMacademy.com
Tuning in gas chromatography–mass spectrometry (GC–MS) involves adjusting several mass spectrometer parameters through the infusion of a tune compound, commonly perfluorotributylamine (PFTBA). The tune report generated is invaluable because it indicates how well the instrument is operating, and is an essential tool when troubleshooting is required. A typical autotune report is shown in Figure 1.
There are several parameters that need to be examined in this autotune report:
All other parameters within the autotune will differ from instrument to instrument, but general trends from subsequent autotune reports should be noted. Any consistent drift in either the positive or negative direction should be noted and then re-autotune, manual tune, or maintenance should be carried out accordingly.
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