Application Notes: Size-Exclusion Chromatography (SEC)

Combining the benefits of the ACQUITY APC System with the ACQUITY UPLC Refractive Index (RI) Detector and the ACQUITY QDa Mass Detector yields laboratory efficiencies.

The selection of appropriate column chemistries to separate eighteen polymer additives are routinely monitored in extractables and leachables (E&L) workflows.

A flexible analytical system was used in conjunction with a well-defined informatics workflow to elucidate degradation markers in Li-Ion battery electrolytes.

Combining the APC System with WinGPC UniChrom™ software allows researchers to increase the peak capacity of their research.

Collaborative efforts at Virginia Tech University drive better materials through polymer innovation and additive manufacturing.

How UHP‑SEC‑MALS analysis using a UHPLC compatible multi-angle light scattering detector can be applied to determine absolute molecular weight of recombinant proteins.

Learn how light scattering characterizes multiple biophysical attributes of different vaccine modalities in support of discovery, development, manufacture, and QC.  

Comprehensive physicochemical characterization of biopolymers is accomplished by adding multi-angle light scattering and differential viscometry to standard SEC.

Branching impacts polymer properties such as rheology and stiffness. This note explains the analysis of branching ratio versus molar mass, accomplished by SEC-MALS(-IV).

How do bioinert and biocompatible liquid chromatography (LC) systems and columns improve separations of biomolecules? How do I know when these systems are required for my separation?

This note demonstrates the ability of a TSKgel® UP-SW2000 SEC column to discriminate oligonucleotides differing by one base in length.

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.

In this note, the molecular weight averages and molecular weight distributions of two hydroxyethyl starch (HES) samples were successfully demonstrated.