Application Notes: Size-Exclusion Chromatography (SEC)

Accelerating Additive Manufacturing Breakthroughs

October 08, 2020

Collaborative efforts at Virginia Tech University drive better materials through polymer innovation and additive manufacturing.

SEC-MALS Analysis of Biotherapeutics

September 24, 2020

How UHP‑SEC‑MALS analysis using a UHPLC compatible multi-angle light scattering detector can be applied to determine absolute molecular weight of recombinant proteins.

Characterizing Vaccines with Light Scattering

September 14, 2020

Learn how light scattering characterizes multiple biophysical attributes of different vaccine modalities in support of discovery, development, manufacture, and QC.

Analysis of Hyaluronic Acid by SEC-MALS-IV

March 19, 2020

Polymer Branching Analysis by SEC-MALS-IV

March 19, 2020

Troubleshooting LC Separations of Biomolecules, Part 1: Background, and the Meaning of Inertness

March 01, 2020

How do bioinert and biocompatible liquid chromatography (LC) systems and columns improve separations of biomolecules? How do I know when these systems are required for my separation?

Analysis of Oligonucleotides by SEC

February 17, 2020

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Analysis of Oligonucleotides by SEC

November 19, 2019

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This note demonstrates the ability of a TSKgel® UP-SW2000 SEC column to discriminate oligonucleotides differing by one base in length.

Quantifying CQAs of gene therapy vectors

October 22, 2019

Sponsored Content - NA

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.

Characterization of Hydroxyethyl Starch Using Gel Permeation Chromatography

September 18, 2019

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In this note, the molecular weight averages and molecular weight distributions of two hydroxyethyl starch (HES) samples were successfully demonstrated.