OR WAIT null SECS
March 26, 2021
We investigated the purification and size-exclusion chromatography and light scattering analysis of virus-like particles.
This application note demonstrates the separation of IgG monomers and its aggregates, antibody metabolites, and other proteins.
LC–MS analysis of various low molecular weight cationic compounds were demonstrated using gradient formic acid and acetonitrile eluents.
Oligonucleotides were then analyzed using liquid chromatography with ultraviolet and mass spectrometry with a polymer-based diol column.
February 11, 2021
This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.
October 09, 2020
Combining the benefits of the ACQUITY APC System with the ACQUITY UPLC Refractive Index (RI) Detector and the ACQUITY QDa Mass Detector yields laboratory efficiencies.
The selection of appropriate column chemistries to separate eighteen polymer additives are routinely monitored in extractables and leachables (E&L) workflows.
A flexible analytical system was used in conjunction with a well-defined informatics workflow to elucidate degradation markers in Li-Ion battery electrolytes.
Combining the APC System with WinGPC UniChrom™ software allows researchers to increase the peak capacity of their research.
October 08, 2020
Collaborative efforts at Virginia Tech University drive better materials through polymer innovation and additive manufacturing.
September 24, 2020
How UHP‑SEC‑MALS analysis using a UHPLC compatible multi-angle light scattering detector can be applied to determine absolute molecular weight of recombinant proteins.
September 14, 2020
Learn how light scattering characterizes multiple biophysical attributes of different vaccine modalities in support of discovery, development, manufacture, and QC.
March 19, 2020
Comprehensive physicochemical characterization of biopolymers is accomplished by adding multi-angle light scattering and differential viscometry to standard SEC.
Branching impacts polymer properties such as rheology and stiffness. This note explains the analysis of branching ratio versus molar mass, accomplished by SEC-MALS(-IV).
March 01, 2020
How do bioinert and biocompatible liquid chromatography (LC) systems and columns improve separations of biomolecules? How do I know when these systems are required for my separation?
February 17, 2020
November 19, 2019
This note demonstrates the ability of a TSKgel® UP-SW2000 SEC column to discriminate oligonucleotides differing by one base in length.
October 22, 2019
September 18, 2019
In this note, the molecular weight averages and molecular weight distributions of two hydroxyethyl starch (HES) samples were successfully demonstrated.