A novel quantitative method combining multiple reaction monitoring (MRM) and ultrahigh‑pressure liquid chromatography coupled to mass spectrometry (UHPLC–MS) has been developed by Carlito Lebrilla and his team to study site-specific glycosylation in manufactured recombinant monoclonal antibody drugs (rmAbs). He spoke to The Column about this research.
Rudolf Krska, from the University of Natural Resources and Life Sciences in Vienna, Austria, talks about the latest analytical techniques and challenges facing analysts involved in the evolving field of mycotoxin analysis.
The Column spoke to Rudolf Krska from the University of Natural Resources and Life Sciences in Vienna, Austria, about the latest analytical techniques and challenges facing analysts involved in the evolving field of mycotoxin analysis.
A cross-disciplinary team of researchers in Tasmania from the fields of separation science, proteomics and metabolomics, immunology and zoology are on a mission to save the Tasmanian devil from extinction using metabolic fingerprinting of serum to identify biomarkers for Devil Facial Tumour Disease (DFTD). The Column spoke to Naama Karu, Rodrigo Hamede Ross, and Richard Wilson to find out more.
Discovering and identifying molecular biomarkers in large liquid chromatography–mass spectrometry (LC–MS) data sets requires automation without loss of accuracy.
Discovering and identifying molecular biomarkers in large liquid chromatography–mass spectrometry (LC–MS) data sets requires automation without loss of accuracy. Benjamin Van Mooy from the Wood Hole Oceanographic Institution reveals a lipidomics strategy using LOBSTAHS to identify lipid, oxidized lipid, and oxylipin biomarkers in high mass accuracy high performance (HP) LC–MS data.
Discovering and identifying molecular biomarkers in large LC–MS data sets requires automation without loss of accuracy. Benjamin Van Mooy from the Wood Hole Oceanographic Institution reveals a lipidomics strategy using LOBSTAHS to identify lipid, oxidized lipid, and oxylipin biomarkers in high mass accuracy HPLC– MS data.
Raquel Garcia and Maria João Cabrita reveal the theory and practical applications of molecularly imprinted polymers (MIPs).
Contaminants in surface water and drinking water supplies arising from pharmaceutical and personal care product use as well as other compound sources pose a difficult challenge for analytical chemists. Thomas Letzel from the Technical University of Munich in Germany, spoke to The Column to discuss collaborative research taking place in Europe to address contaminants of emerging concern in water analysis.
Protein biopharmaceuticals have seen an enormous growth in the last decade, and as a result, separation scientists are giving increased attention to methods for characterizing biopharmaceuticals. One powerful technique for analyzing proteins is two-dimensional liquid chromatography (2D LC). Gerd Vanhoenacker of the Research Institute for Chromatography (RIC) in Kortrijk, Belgium, has been conducting research into peptide mapping of therapeutic monoclonal antibodies (mAbs) using 2D LC. He recently spoke to The Column about this work.
Contaminants in surface water and drinking water supplies arising from pharmaceutical and personal care product use as well as other compound sources pose a difficult challenge for analytical chemists. Thomas Letzel from the Technical University of Munich in Germany spoke to LCGC to discuss collaborative research taking place in Europe to address contaminants of emerging concern in water analysis.
Populations worldwide are exposed to polychlorinated biphenyls (PCBs) that can be harmful to human health. The Column spoke to David Megson from Ryerson University in Toronto, Canada, about recent developments in assessing human exposure to PCBs and chiral enantiomer fractions (EFs) in the workplace.
A new chromatographic method to detect paralytic shellfish toxins (PSTs) in food has been developed by a team of scientists from the Swedish Research Agency.PSTs pose a threat to seafood and drinking water from natural contamination, but could also be used to deliberately contaminate food, according to the authors.
Marine polychaetes are a common type of annelid worm widely spread in marine environments. Raquel Fernandez from the University of Copenhagen, Denmark, spoke to Aladair Matheson of The Column about her innovative approach to developing an untargeted method to monitor polychaetes and assess their potential use in environmental monitoring of oil spills.
The Kendrick mass defect combined with liquid chromatography quadrupole time-of-flight mass spectrometry (LC–QTOF-MS) can offer a variety of benefits to analysts investigating groundwater contamination. The Column spoke to Thomas Borch from Colorado State University in Colorado, USA, about his work in this area to find out more.
Bryan Vining from SGS Environmental Service (Wilmington, North Carolina, USA) reveals some of the cutting-edge research his team has performed involving dioxin analysis, and proposes some future possibilities for the direction of this field.
The Column spoke to Dr. Rob Haselberg from the VU University Amsterdam, The Netherlands, about his work characterizing proteins using capillary electrophoresis.
The Column spoke to Tony Edge of Thermo Fisher Scientific about the development of a new type of stationary phase based on fractal-shaped particles.
The study of sewage using chromatographic techniques is a rapidly expanding area that can provide insights into the consumption of illicit drugs. Measuring illicit drug concentrations can provide authorities with a close to real time identification of consumption trends and rates in specific geographical areas.
Chris Reddy from the Woods Hole Oceanographic Institution (WHOI) spoke to The Column about the role of chromatography in the ongoing environmental analysis of the Deepwater Horizon oil spill.
Chris Reddy from the Woods Hole Oceanographic Institution (WHOI) spoke to Alasdair Matheson of The Column about the role of chromatography in the ongoing environmental analysis of the Deepwater Horizon oil spill, how GC×GC works in practice, and why this oil spill led to the return of thin layer chromatography (TLC) to his laboratory.
An interview with Merck's Christopher Welch about high-throughput analysis using MISER chromatography and how it can boost your laboratory's productivity.
Wednesday?s Pittcon Audio & Video Theater will be dedicated to CHROMacademy. CHROMacademy is a cutting-edge e-learning programme that LCGC is launching in collaboration with Crawford Scientific. The site will provide continual professional development for chromatographers to make them more effective in the workplace.
Monday morning LCGC North America and LCGC Europe will launch the first Pittcon Theater sessions. This cutting-edge multimedia project will include live interviews with leading experts from the world of analytical chemistry and will cover the latest developments, applications and trends in the fields of chromatography and spectroscopy. Editor-in-chief of LCGC North America, Dave Walsh and Editorial Director of LCGC Europe, Peter Houston, will host these illuminating sessions.
Tuesday morning LCGC North America and LCGC Europe continue with the second part of the Pittcon Theater sessions. Today's sessions will cover MS/Hyphenated techniques and Spectroscopy.
LCGC Europe has revamped its digital media portfolio to complement the peer-reviewed magazine.
Research Group: Professor Maria Celia Garcia-Ãlvarez-Coque, Department of Analytical Chemistry, Faculty of Chemistry, University of Valencia, Valencia, Spain.
Research group: Professor Jane Thomas-Oates, Analytical, Environmental and Atmospheric Chemistry, Department of Chemistry, University of York, York.
