
The panel concludes by envisioning the future of PFAS research and analysis.

Carrie McDonough, Ph.D. is an assistant professor in the Department of Chemistry at Carnegie Mellon University (CMU), where she leads a research group focused on environmental analytical chemistry. She teaches two courses at CMU, Analytical Chemistry and Environmental Exposure & Risk Assessment. McDonough works at the intersection of analytical chemistry, environmental chemistry, and chemical biology. She received her B.Sc. in Chemistry from the Massachusetts Institute of Technology (MIT) in 2008 and Ph.D. in Chemical Oceanography from the University of Rhode Island Graduate School of Oceanography (URI GSO) in 2017. Her dissertation focused on measuring air-water diffusive exchange of hydrophobic organic contaminants in the Great Lakes and Canadian Arctic using polyethylene passive samplers. She then completed a postdoctoral fellowship at Colorado School of Mines, where she developed nontarget high-resolution mass spectrometry methods for per/polyfluoroalkyl substances (PFASs) in biological fluids to investigate toxicokinetics of complex PFAS mixtures and human exposure to novel PFASs. Broadly, McDonough's current research explores how the molecular structure and chemical properties of pollutants influence their fate in the environment and their biological effects. Her overarching objective is to develop analytical and bioanalytical strategies to identify and prioritize particular contaminants of concern for remediation and toxicological investigation.

The panel concludes by envisioning the future of PFAS research and analysis.

The conversation turns to collaboration—highlighting the value of cross-sector partnerships in advancing PFAS science, securing funding, and fostering scientific progress.

Panelists discuss the creation and use of PFAS libraries and databases, stressing the need for comprehensive, up-to-date resources to support accurate compound identification.

Scientists examine the role of non-targeted analysis in discovering unknown PFAS, and how automation and data processing tools are accelerating this work.

The panel examines how evolving global regulations are shaping approaches to PFAS analysis, while also highlighting how ongoing research enhances our understanding of these contaminants and informs regulatory decision-making.

In this episode the panelists unpack how laboratories can reduce background contamination and improve sensitivity through rigorous method optimization and instrument handling.

The panelists discuss the challenges of analyzing short-chain PFAS and highlights how emerging techniques like ion mobility offer promising solutions.

In this episode the panelists explore emerging analytical techniques that are enhancing PFAS quantification.

The experts explore the most pressing analytical challenges in PFAS analysis, highlighting persistent issues such as contamination, detection limits, background blanks, and other method-related obstacles encountered in the lab.

The panelists introduce their backgrounds, research focus areas, and what drew them into the field of PFAS analysis, setting the stage for a deep dive into current challenges and innovations.