News|Videos|June 24, 2025
Advancing and Automating Non-Targeted Analysis
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Scientists discuss how non-targeted analysis is uncovering previously unknown PFAS, expanding our understanding of these complex contaminants. They also highlight how automation and advanced data processing tools are accelerating discovery and improving analytical efficiency.
To watch the full series of videos from this peer exchange,
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Laura Righetti explains why quantification, not instrumentation, still keeps mass spectrometry imaging (MSI) out of routine food safety testing.
Anneli Kruve reports that toxicity predictions from MS2-derived molecular fingerprints outperform spectral-similarity methods in nontarget screening of food.
Quantitative non-targeted screening with predicted response factors is not for regulation, but can rank environmental chemicals by concentration and toxicity.
In this seventh part of " Conversations with Michael Dong," a series on fundamentals of HPLC in pharmaceutical analysis, LCGC International’s "Perspectives in HPLC" column editor explains why 2.1-mm i.d. columns are less preferred for pharmaceutical quality control.
Ultrahigh-performance liquid chromatography–quadrupole time-of-flight mass spectrometry (UHPLC–QTOF-MS) shows how soaking and cooking break down soybean fats.
Liquid chromatography–tandem mass spectrometry (LC–MS/MS) links altered metabolism to lingering symptoms in Ebola survivors.
Nicolai Zederkopff explores chromatography’s role to help implement the maximum tolerable level (MTL) framework for food adulteration to translate analytical results into compliance decisions.
Franz Berthiller (BOKU University, Austria) discusses a multilaboratory study that used retention index markers to align mycotoxin liquid chromatography–mass spectrometry (LC–MS) data.
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