John Chasse

Researchers at the University of Buffalo used combined middle-up and bottom-up LC–MS/MS to characterize the HIV-1 broadly neutralizing antibody PGT 121. They identified multiple Fc and site-specific glycoforms and an unexpected N-terminal serine, revealing significant structural heterogeneity. This integrated approach enhances understanding of bNAb structure, supporting quality control and clinical development. LCGC International spoke to Troy Wood, corresponding author of the paper resulting from this research.

Researchers focused on the early stages of developing innovative plant-based active ingredients for skincare, using HPLC to determine which species should be shortlisted for phytochemical profiling.

Metabolomic profiling and the identification of metabolomic markers following HPAI H5N1 infection in chicken was performed in an Indian research study, with metabolite extracts analyzed using LC-MS/MS.

Researchers evaluated the antidiabetic potential of peanut oil, known for its high phytochemical content and medicinal properties, using GC-MS to collect and classify fatty acid compounds within the oil.

The advancements in HILIC–MS for oligonucleotide analysis are discussed, highlighting its potential as a viable alternative to traditional methods.

The second part of our interview with Annika van der Zon and Andrea Gargano regarding their research developing poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic hydrophilic interaction chromatography columns optimized for protein separation.

Researchers assessed ivermectin (IVM) residues in intensive swine farms—from animal treatment to slurry, soil, and wastewater—to evaluate potential environmental contamination. IVM concentrations were quantified using LC–MS/MS.

In a study conducted at the van 't Hoff Institute for Molecular Sciences at the University of Amsterdam (the Netherlands), researchers developed poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic HILIC columns optimized for protein separation.LCGC International spoke to Annika van der Zon and Andrea Gargano, both from the van 't Hoff Institute and corresponding authors of the paper, to learn more about their research

Thermo Fisher Scientific has released the Orbitrap Exploris EFOX Mass Detector, a high-resolution mass spectrometry system for environmental and food safety testing.

Researchers used GC-IMS technology to analyze the volatile flavor compounds in different plum varieties and the changes in flavor during the salting process.

A study to illustrate the metabolic changes in the adipose tissue metabolome of Holstein dairy cows transitioning from one lactation cycle to the next integrated liquid chromatography, flow injection, and electrospray ionization triple quadrupole MS.

A joint study by India’s Mohanlal Sukhadia University and the Central University of Punjab identified fungal pathogens linked to ginger rhizome rot and analyzed their effects and mycotoxins using molecular and chromatographic techniques.

A recent study examined single-particle inductively coupled plasma time-of-flight mass spectrometry (SP-ICP-TOF-MS) as a novel technique for uranium particle isotope ratio measurements.LCGC International spoke to Benjamin Manard, Senior R&D Staff Scientist and the Group Leader of the Chemical & Isotopic Mass Spectrometry Group at Oak Ridge National Laboratory (ORNL) as well as to Sarah Szakas and Jordan Stanberry, postdoctoral researchers at ORNL, three of the authors of the paper that resulted from this study.

Recognizing that the long-term fate of tire and road wear particles (TRWP) influences the distribution of tire-related chemicals, researchers at the Helmholtz Centre for Environmental Research analyzed 27 polar and moderately polar compounds by LC–MS, including para-phenylenediamines, phenylguanidines, benzothiazoles, and known transformation products.

Knauer Wissenschaftliche Geräte GmbH has acquired Labomatic AG (Möhlin, Switzerland). The acquisition expands the Berlin, Germany scientific equipment manufacturer’s portfolio in preparative high-performance liquid chromatography (HPLC), particularly with HPLC systems designed for flow rates of up to 540 liters per hour.

A joint study conducted by United States Department of Agriculture and Pomona College developed a healthy, marketable juice by combining the nutritional benefits of noni fruit juice with the palatability of pineapple juice and then evaluating the physical, chemical, and sensory properties of the resulting blend.

Researchers found that blood collection tubes from different manufacturers can interfere with LC-MS/MS measurement of serum 25-hydroxyvitamin D [25(OH)D], a critical preanalytical quality control issue affecting assay accuracy.

Research conducted at the Federal University of Campina Grande developed an active pharmaceutical ingredient (API) derived from Psilocybe mushrooms for application in the management of mental health disorders.

Waters Corporation announced the Waters Xevo Charge Detection Mass Spectrometer for the measurement and characterization of mega-mass biomolecules central to next-generation therapeutics and structural biology.

A recent study expanded PFAS biomonitoring in hair to 26 analytes—including fluorotelomer sulfonic and carboxylic acids, FTUCAs, diPAPs, diSAmPAP, FOSA, N-EtFOSAA, and the ionic liquid NTf2—to characterize exposure patterns in non-occupationally exposed individuals and explore links with physical and lifestyle factors. LCGC International spoke to Miriam Haußecker, lead author of the paper that resulted from this study.

Researchers utilized HS-SPME-GC-MS combined with relative odor activity values (rOAV) analysis to investigate the temporal dynamics of volatile metabolites during long-term cigar aging.

Researchers from the University of Toledo and Wayne State University investigated the prognostic importance of oxylipins in a cohort of 90 participants with heart failure with preserved ejection fraction (HFpEF) with preserved ejection fraction over a 5-year period used high-performance liquid chromatography (HPLC) to extract polyunsaturated fatty acyl (PUFA) metabolites from serum samples.

Research conducted by the University of Tolima evaluated the effects of chromium-yeast supplementation at different doses and timepoints on physiological and molecular stress biomarkers in heat-stressed lambs, with chromium bioavailability assessed by blood levels using absorption chromatography.

Researchers characterized lipid profiles from Hass Portuguese avocado pulp using C18 reversed-phase HPLC-MS/MS, and their biological activities were evaluated.

A recent joint study by the University of Lyon (Villeurbanne, France) and the University of Texas at Arlington studied the chromatographic variations induced by replacing classical solvents with carbonate esters using simple reverse phase liquid chromatography (RPLC), hydrophilic interaction chromatography (HILIC), and normal phase liquid chromatography (NPLC) separations of model compounds. LCGC International spoke to Sakil Islam, one of the authors of the resulting paper.

Researchers at the Spanish National Research Council’s Institute of Marine Research published a review article exploring MS-based approaches for the detection and quantification of seafood allergens, with a focus on technological advancements, current challenges, and future perspectives to enhance food safety and regulatory compliance.

Researchers evaluated hair care formulations containing 0.5–1.5% fractionated patchouli oil (LFPO) for antidandruff activity against M. globosa and hair growth effects in male rabbits. LFPO, derived from crude patchouli oil (CPO), was characterized using GC-MS to enhance efficacy.

Wenzhou University researchers developed a comprehensive broccoli volatile metabolite database using SPME-GC-HRMS with dual ionization (EI and CI), analyzing 191 cultivars to capture wide chemical diversity for metabolomics, cultivar differentiation, and quality assessment.

Building on the initial discovery of unidentified extractable organic fluorine (EOF) in Greenland killer whale blubber, researchers characterized EOF in additional specimens and identified some of their origins using gas chromatography-atmospheric pressure chemical ionization-high resolution mass spectrometry (GC-APCI-IMS).

LCGC International spoke to Szabolcs Fekete of Waters Corporation, corresponding author of a recent paper which introduces and validates a novel separation quality factor (SQF) metric, designed to overcome the limitations of existing performance descriptors by integrating multiple normalized and weighted criteria into a single score.