John Chasse

Articles by John Chasse

Researchers at the University of Buffalo used combined middle-up and bottom-up LC–MS/MS to characterize the HIV-1 broadly neutralizing antibody PGT 121. They identified multiple Fc and site-specific glycoforms and an unexpected N-terminal serine, revealing significant structural heterogeneity. This integrated approach enhances understanding of bNAb structure, supporting quality control and clinical development. LCGC International spoke to Troy Wood, corresponding author of the paper resulting from this research.

In a study conducted at the van 't Hoff Institute for Molecular Sciences at the University of Amsterdam (the Netherlands), researchers developed poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic HILIC columns optimized for protein separation.LCGC International spoke to Annika van der Zon and Andrea Gargano, both from the van 't Hoff Institute and corresponding authors of the paper, to learn more about their research

A recent study examined single-particle inductively coupled plasma time-of-flight mass spectrometry (SP-ICP-TOF-MS) as a novel technique for uranium particle isotope ratio measurements.LCGC International spoke to Benjamin Manard, Senior R&D Staff Scientist and the Group Leader of the Chemical & Isotopic Mass Spectrometry Group at Oak Ridge National Laboratory (ORNL) as well as to Sarah Szakas and Jordan Stanberry, postdoctoral researchers at ORNL, three of the authors of the paper that resulted from this study.

A recent study expanded PFAS biomonitoring in hair to 26 analytes—including fluorotelomer sulfonic and carboxylic acids, FTUCAs, diPAPs, diSAmPAP, FOSA, N-EtFOSAA, and the ionic liquid NTf2—to characterize exposure patterns in non-occupationally exposed individuals and explore links with physical and lifestyle factors. LCGC International spoke to Miriam Haußecker, lead author of the paper that resulted from this study.

Researchers from the University of Toledo and Wayne State University investigated the prognostic importance of oxylipins in a cohort of 90 participants with heart failure with preserved ejection fraction (HFpEF) with preserved ejection fraction over a 5-year period used high-performance liquid chromatography (HPLC) to extract polyunsaturated fatty acyl (PUFA) metabolites from serum samples.

A recent joint study by the University of Lyon (Villeurbanne, France) and the University of Texas at Arlington studied the chromatographic variations induced by replacing classical solvents with carbonate esters using simple reverse phase liquid chromatography (RPLC), hydrophilic interaction chromatography (HILIC), and normal phase liquid chromatography (NPLC) separations of model compounds. LCGC International spoke to Sakil Islam, one of the authors of the resulting paper.

Researchers at the Spanish National Research Council’s Institute of Marine Research published a review article exploring MS-based approaches for the detection and quantification of seafood allergens, with a focus on technological advancements, current challenges, and future perspectives to enhance food safety and regulatory compliance.

Researchers evaluated hair care formulations containing 0.5–1.5% fractionated patchouli oil (LFPO) for antidandruff activity against M. globosa and hair growth effects in male rabbits. LFPO, derived from crude patchouli oil (CPO), was characterized using GC-MS to enhance efficacy.

Building on the initial discovery of unidentified extractable organic fluorine (EOF) in Greenland killer whale blubber, researchers characterized EOF in additional specimens and identified some of their origins using gas chromatography-atmospheric pressure chemical ionization-high resolution mass spectrometry (GC-APCI-IMS).