John Chasse

Researchers profiled and compared metabolites in drought-tolerant and drought-susceptible sweet potato cultivars under water-deficient conditions. Leaf samples were collected and analyzed for metabolite changes using untargeted ultra-performance liquid chromatography-mass spectrometry (UPLC-MS).

A joint study between Amsterdam University Medical Centers and MEDLAB analyzed over two dozen glucose sensors, insulin pumps, and insulin infusion sets to identify the chemicals present in these devices using gas chromatography–mass spectrometry (GC–MS).

Using advanced chromatography–mass spectrometry techniques, researchers mapped how metabolites move between coral tissue and skeleton, uncovering clear metabolic differences across tissue and skeletal layers.

Georgia Tech and NASA used advanced chromatography and a new computational tool to compare organic compounds in meteorite and terrestrial rock samples.

Researchers investigating the role of cholesterol metabolism disorders in the etiopathogenesis of autism spectrum disorder (ASD) through the analysis of central and peripheral oxysterol levels assessed those levels using liquid chromatography coupled with tandem mass spectrometry (LC-MS/MS).

Researchers analyzed 200 mustard samples using gas chromatography with flame ionization detection (GC-FID) to determine their fatty acid profile, with a specific focus on erucic acid (EA) content.

Researchers at Iran’s Islamic Azad University investigated the fatigue and cracking behavior of aged asphalt modified with various percentages of recycled and conventional rejuvenators commonly used in Iran using gel permeation chromatography.

Researchers at Wageningen Food Safety Research (WFSR), part of Wageningen University & Research (The Netherlands), developed a manually curated open-access LC–HRMS/MS spectral library of 1001 food toxicants and 6993 spectra. LCGC International spoke with WFSR’s Ivan Aloisi about the work.

Researchers from China’s Southwest Medical University and The First People's Hospital explored metabolic associations and pathways in acne comorbid with depression via untargeted metabolomics using UHPLC-MS.

This edition of LCGC International’s “Equipment Roundup” spotlights Shimadzu’s i-Series LC-2070/LC-2080 Integrated High-Performance Liquid Chromatographs, and recent software upgrades to their ACD/Labs Spectra and Percepta platforms.

Researchers from Italian institutions investigated how the storage and transport of cocoa beans in jute bags from 15 countries contribute to mineral oil hydrocarbon (MOH) contamination, finding—using advanced chromatographic techniques including GC×GC-FID/MS.

A Purdue University team published a comprehensive review highlighting two decades of research advancing desorption electrospray ionization-mass spectrometry (DESI-MS) as a rapid, sensitive, and clinically valuable tool for improving surgical precision and patient outcomes in neuro-oncology.

Researchers at Fairleigh Dickinson University (Florham Park, New Jersey) published a study in Analytica that investigated the retention mechanisms of 16 native and modified nucleosides on a bare silica column in hydrophilic interaction liquid chromatography (HILIC). LCGC International spoke to Yong Guo, Professor of Pharmaceutical Science and Chair of the Department of Pharmaceutical Sciences at the Fairleigh Dickinson’s College of Pharmacy and Health Sciences, and corresponding author of the paper, about the group’s findings.

Researchers have developed a sensitive and selective GC–MS method for the simultaneous qualitative and quantitative analysis of multiple sterols in pre-prepared dishes.

A study focusing on the identification and characterization of a novel antioxidant peptide from black soybean aqueous extracts, targeting myeloperoxidase (MPO), a key enzyme in oxidative damage profiled the peptide components using LC-MS/MS.

A multinational research study assessed microplastic concentrations in the drinking water supply system of Amsterdam from source to tap using pyrolysis gas chromatography-mass spectrometry (Py-GC-MS).

A multinational research group developed and validated an in-house sample preparation procedure and liquid chromatography with tandem mass spectrometry (LC-MS/MS) method to monitor the suspected carcinogen acrylamide (AA) in 113 potato chip samples from Iranian brands during two periods: 2016-2017 and 2020-2021.

Researchers from the United Kingdom’s National Measurement Laboratory (NML) developed and evaluated a tailored mass spectrometry (MS)-based workflow for the detailed characterization and quantification of rAAV serotype 9 (rAAV9) capsid proteins.LCGC International spoke to Theodoros Kontogiannis from the NML and the lead author of the paper that resulted from this work, about the group’s findings.

Researchers have developed an enhanced LC-MS/MS method capable of quantifying 18 steroids—including key corticosteroid and sex steroid hormones, as well as intermediates involved in corticosteroid synthesis—in plasma and tail samples collected during the transition of tadpoles into frogs.

Research focused on the cooking process of marinades used headspace solid-phase microextraction gas chromatography-mass spectrometry to analyze changes and volatilization characteristics of flavor compounds at different cooking times.

A study conducted by a multinational research group investigated the potential of audible sound waves (in the form of music, specifically Pink Floyd’s "Another Brick in the Wall, Part 1") in enhancing nanoparticle neuronal uptake and brain penetration.

Researchers at Oregon State University and Dow Neurobiology developed a standardized aroma lexicon for characterizing the aromatic attributes of Cannabis inflorescence with an associated sensory method that included the use of gas chromatography in data analysis.

Researchers at the University of Buffalo used combined middle-up and bottom-up LC–MS/MS to characterize the HIV-1 broadly neutralizing antibody PGT 121. They identified multiple Fc and site-specific glycoforms and an unexpected N-terminal serine, revealing significant structural heterogeneity. This integrated approach enhances understanding of bNAb structure, supporting quality control and clinical development. LCGC International spoke to Troy Wood, corresponding author of the paper resulting from this research.

Researchers focused on the early stages of developing innovative plant-based active ingredients for skincare, using HPLC to determine which species should be shortlisted for phytochemical profiling.

Metabolomic profiling and the identification of metabolomic markers following HPAI H5N1 infection in chicken was performed in an Indian research study, with metabolite extracts analyzed using LC-MS/MS.

Researchers evaluated the antidiabetic potential of peanut oil, known for its high phytochemical content and medicinal properties, using GC-MS to collect and classify fatty acid compounds within the oil.

The advancements in HILIC–MS for oligonucleotide analysis are discussed, highlighting its potential as a viable alternative to traditional methods.

The second part of our interview with Annika van der Zon and Andrea Gargano regarding their research developing poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic hydrophilic interaction chromatography columns optimized for protein separation.

Researchers assessed ivermectin (IVM) residues in intensive swine farms—from animal treatment to slurry, soil, and wastewater—to evaluate potential environmental contamination. IVM concentrations were quantified using LC–MS/MS.

In a study conducted at the van 't Hoff Institute for Molecular Sciences at the University of Amsterdam (the Netherlands), researchers developed poly(acrylamide-co-N,N-methylene-bis(acrylamide) monolithic HILIC columns optimized for protein separation.LCGC International spoke to Annika van der Zon and Andrea Gargano, both from the van 't Hoff Institute and corresponding authors of the paper, to learn more about their research