Michael McCoy

home / authors / michael-mccoy

Articles

i2-726880-1408617465983.gif

Enantiomeric Separation of Proton Pump Inhibitors Using Polysaccharide-Based Chiral Stationary Phases in Reversed-Phase HPLC Conditions

Michael McCoy;Kari Carlson;Phenomenex, Inc.;Liming Peng;Jeff Layne
June 1st 2011

The chiral analysis and purification of proton pump inhibitors (PPIs) has become a popular topic as more of these drugs fall out of patent protection each year. Due to their wide range of enantiomeric selectivity, a set of polysaccharide-based chiral stationary phases (CSPs) was screened to identify methods for the successful enantioseparation of four benzimidazoles; rabeprazole, lansoprazole, omeprazole, and pantoprazole.

Latest Updated Articles

Technology Trends in Separation Science: Data Handling
Published: July 3rd 2024 | Updated: July 8th 2024
Technology Trends in Separation Science: Data Handling
Human monoclonal antibody to fight cancer | Image Credit: © Yuriy - stock.adobe.com
Published: June 28th 2024 | Updated: October 24th 2024
Analysis of Therapeutic Monoclonal Antibodies Using a Platform Size Exclusion-HPLC Method
Virus protection. Vaccine search. Antibodies and viral infection. Immune defense of the body. Attack on antigens 3D illustration By Siarhei - stock.adobe.com
Published: July 16th 2024 | Updated: October 24th 2024
Characterization of Product Related Variants in Therapeutic Monoclonal Antibodies
Chromatograph with glass sample bottles | Image Credit: © JJIMAGE - stock.adobe.com
Published: September 10th 2024 | Updated: October 24th 2024
Analytical Method Lifecycle of SFC Methods from Development Use to Routine QC Implementation; Supporting Small Molecule R&D and Commercialization
Glass vial, pipette and woman scientist in laboratory for medical study, research or experiment. Test tube, dropper and professional female person with chemical liquid for pharmaceutical innovation. | Image Credit: © peopleimages.com - stock.adobe.com
Published: September 16th 2024 | Updated: October 24th 2024
Are You Sure You Understand USP <621>?
Scientist moved the vial of sample out from the tray autosampler of the Liquid Chromatography Mass Spectrometer LC/MS after the analysis was complete. | Image Credit: © S. Singha - stock.adobe.com
Published: September 13th 2024 | Updated: October 24th 2024
In-Loop Analyte Degradation in Two-Dimensional Liquid Chromatography: Example and Solutions