Peter W. Carr

In his article, published in 2000, David V. McCalley found large increases in the efficiency for basic compounds at elevated temperature

Despite the utility of high performance liquid chromatography (HPLC) simulators, we found that all the free and low-cost simulators were outdated or had extremely limited functionality, so we created one that addressed these shortcomings. We developed a sophisticated, open-source HPLC simulator that is available for free as well as a version for Android users called "HPLC Simulator." Here we discuss a few questions that the simulator can help answer: Why are peaks narrower in gradient elution? What is gradient delay and how does it affect a separation?

The guest authors describe an optimization procedure to achieve the highest plate count in a given analysis time.

Well-known industry veteran and LCGC EAB member Peter Carr looks back at the early days of the chromatography field and reflects on his own experiences.

We focus on the characterization of reversed-phase columns with particular emphasis on the hydrophobic-subtraction model

We focus on the characterization of reversed-phase columns with particular emphasis on the hydrophobic-subtraction model

In 2001, the second glossary of common and not-so-common terms and "buzz words" for reference to HPLC columns and column technology was published. It is time for an update since new terms have arisen or, in some cases, their original meanings have expanded or changed.

The authors compare thermally tuned tandem column separations with single-column optimization strategies.

A single-source reference for key chromatography terms.

During the past five years, many manufacturers of HPLC columns have focused on improving stationary phase stability and reproducibility. In this study, the authors use a variety of test solutes to compare the efficiency, selectivity, and hydrophobic retention mechanisms of five commercially available HPLC columns based silica, alumina, zirconia, and polystyrene cross-linked with divinylbenzene as the support.