Wyatt Technology Corporation

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio. 

Characterization of technical polymers by light scattering and field-flow fractionation (FFF-MALS) is reviewed and contrasted with the more common technique, SEC-MALS.

FFF-MALS-DLS provides the detailed characterization of nano-pharmaceuticals that is essential for development and regulatory filing.

*** Three Events: Tuesday, Oct. 27, 2020 at 11am EDT| 8am PDT| 3pm GMT| 4pm CET Asia Pacific: Wednesday, Oct. 28, 2020 at 10:30 am IST| 1pm CST| 2pm JST Europe: Wednesday, Oct. 28, 2020 at 9am| 10am CET*** Characterizing complex nanoparticles, polymers and biotherapeutics is about to get a lot easier. ***On demand available after final airing until Oct. 28, 2021***

Learn how light scattering characterizes multiple biophysical attributes of different vaccine modalities in support of discovery, development, manufacture, and QC.  

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.

This note describes how SEC-MALS-UV-RI analysis quantifies multiple critical quality attributes of AAV viral vectors, including concentration/titer, aggregation and empty:full ratio.

Branching impacts polymer properties such as rheology and stiffness. This note explains the analysis of branching ratio vs. molar mass, accomplished by SEC-MALS( -IV).

SEC-MALS analyzes proteins, peptides, nucleic acids, polysaccharides and bionanoparticles to determine molar mass, size, conjugation, aggregation and interactions.

• FFF–MALS offers deep and unbiased particle characterization. • Regulatory bodies view FFF–MALS as essential for various nanomedicines.