Wyatt Technology Corporation

This note discusses the characterization of conformational properties of hyperbranched macromolecules by combining SEC-MALS with differential viscometry.

This note discusses the characterization of conformational properties of hyperbranched macromolecules by combining SEC-MALS with differential viscometry.

Tuesday December 14, 2021 at 11am EST | 8am PST Join us to learn how developing sustainable thermoplastics is facilitated by SEC-MALS.

The performance of hyaluronic acid is closely tied to its molar mass, intrinsic viscosity, and molecular conformation, quantified absolutely by multi-detector SEC.

Field-flow fractionation coupled to online light scattering detectors determines detailed size and structural information for nanoparticle-based therapeutics.

Multi-angle light scattering couples inline with ion exchange chromatography to estimate the aggregate content of protein fractions without additional offline assays.

AAV characterization and stability screening are achieved with multi-angle light scattering coupled to separation methods and high-throughput dynamic light scattering.

Tuesday, July 27, 2021 at 11am EDT | 8am PDT | 4pm BST | 5pm CEST Shining a light on conjugated polymers.

Learn how AAVs are characterized for critical quality attributes and stability by multi-angle and dynamic light scattering.

*** Asia Pacific: Thursday, May 27, 2021 at 9am CST | 10am JST | 11am AEST *** Nanopharmaceuticals: the latest in standardized methods for characterization and quantification***On demand available after final airing until May 27, 2022***

*** Wednesday, May 12, 2021 at 11am EDT | 10am CDT | 4pm BST | 5pm CEST*** Multi-angle light scattering (MALS) detection, following an analytical separation technique such as SEC or FFF, can provide detailed information about the molecular structure and thus proper understanding of the properties and behavior of a wide range of polymers. Join us for this web seminar to learn how to apply MALS to polymer analysis. ***On demand available after final airing until May 12, 2022***

As one of the most promising in-vivo gene delivery vectors, adeno-associated virus (AAV) has been widely used in various gene therapy products. In order to ensure the safety and efficacy of these AAV-based gene therapy products, it is crucial to understand and measure their critical quality attributes (CQAs) throughout the development cycle. In this podcast, we will discuss how to apply a well-established bio-therapeutics characterization tool, SEC-MALS (size-exclusion chromatography combined with multi-angle light scattering and other online concentration detectors), for quantifying AAV CQAs. This SEC-MALS method has been recognized and demonstrated as a robust, sensitive, and automated assay for AAV development platform and production release testing.

Field-flow fractionation coupled to online light scattering detectors determines detailed size and structural information for nanoparticle-based therapeutics.

This application note reviews how multi-angle and dynamic light scattering provide accurate, precise measurements of the biophysical attributes of AAV gene vectors.

Learn how SEC coupled to multi-angle light scattering and viscometric detectors determines absolute molar mass, size and conformation of highly complex biopolymers.