Zachary S. Breitbach

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Zachary S. Breitbach is with AbbVie Inc., Small Molecule Analytical R&D Department of AbbVie Inc., in North Chicago, Illinois.

Articles

pharmaceutical glass bottles production line | Image Credit: © Kadmy - stock.adobe.com

A Standardized 2D-LC Screening Platform for Peak Purity Determination in Pharmaceutical Analysis

June 1st 2023

This study suggests a 2D-LC screening method to evaluate peak purity and ensure specificity in pharmaceutical analysis, thereby promoting the safe production of medicines by detecting active pharmaceutical ingredients (API) and related substances.

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Mixing and Mixers in Liquid Chromatography, Part 3: Solutions for Problems with Sample Diluents

June 1st 2019

Adding an inline mixer between the sample injector and column in a liquid chromatography (LC) system can be an effective way to resolve problems with peak shape caused by the sample diluent.

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High Efficiency Chiral Separations in HPLC and SFC

February 1st 2018

In advance of PittconIn advance of Pittcon 2018, leading scientists-Ronald Majors, Richard Henry, John W. Dolan, Zachary S. Breitbach, and Daniel W. Armstrong-who will be speaking at the LCGC awards symposium give us a preview of their talks.

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Comparison of Enantiomeric Separations and Screening Protocols for Chiral Primary Amines by SFC and HPLC

January 1st 2015

SFC was evaluated as an alternative to HPLC for the enantiomeric separation of primary amines on a cyclofructan-based CSP.

Comparison of Enantiomeric Separations and Screening Protocols for Chiral Primary Amines by SFC and HPLC

Comparison of Enantiomeric Separations and Screening Protocols for Chiral Primary Amines by SFC and HPLC

September 1st 2014

Supercritical (subcritical) fluid chromatography (SFC) was evaluated as an alternative to HPLC for the enantiomeric separation of primary amines on a cyclofructan-based chiral stationary phase.