This study suggests a 2D-LC screening method to evaluate peak purity and ensure specificity in pharmaceutical analysis, thereby promoting the safe production of medicines by detecting active pharmaceutical ingredients (API) and related substances.
Zachary S. Breitbach
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Zachary S. Breitbach is with AbbVie Inc., Small Molecule Analytical R&D Department of AbbVie Inc., in North Chicago, Illinois.
Articles by Zachary S. Breitbach
Adding an inline mixer between the sample injector and column in a liquid chromatography (LC) system can be an effective way to resolve problems with peak shape caused by the sample diluent.
In advance of PittconIn advance of Pittcon 2018, leading scientists-Ronald Majors, Richard Henry, John W. Dolan, Zachary S. Breitbach, and Daniel W. Armstrong-who will be speaking at the LCGC awards symposium give us a preview of their talks.
SFC was evaluated as an alternative to HPLC for the enantiomeric separation of primary amines on a cyclofructan-based CSP.
Supercritical (subcritical) fluid chromatography (SFC) was evaluated as an alternative to HPLC for the enantiomeric separation of primary amines on a cyclofructan-based chiral stationary phase.
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Latest Updated Articles
A Standardized 2D-LC Screening Platform for Peak Purity Determination in Pharmaceutical AnalysisPublished: June 1st 2023 | Updated:
Comparison of Enantiomeric Separations and Screening Protocols for Chiral Primary Amines by SFC and HPLCPublished: September 1st 2014 | Updated:
Comparison of Enantiomeric Separations and Screening Protocols for Chiral Primary Amines by SFC and HPLCPublished: January 1st 2015 | Updated:
High Efficiency Chiral Separations in HPLC and SFCPublished: February 1st 2018 | Updated:
Mixing and Mixers in Liquid Chromatography, Part 3: Solutions for Problems with Sample DiluentsPublished: June 1st 2019 | Updated:
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