The Column-12-07-2016

Luis A. Colón and Purnendu (Sandy) Dasgupta have been honoured at the Eastern Analytical Symposium in Somerset, New Jersey, USA, for achievements in their respective fields.

Following their successful “Grass Roots” educational event held in the Lake District, The Chromatography Society (ChromSoc) has announced plans for further events in the same format for 2017.

Researchers from the Scientific Institute of Public Health, in Brussels, Belgium, have devised a simple dilute and shoot methodology for the identification and quantification of illegal insulin (1).

Peak Scientific has been awarded the “Best New Exporter to China Award” at the British Business Awards, held in Shanghai by the British Chamber of Commerce.

In recent years, liquid chromatography–tandem mass spectrometry (LC–MS/MS) methods have been increasingly adopted as a replacement for ligand‑binding assays to monitor the fate of drugs in vivo. Such bioanalysis of protein-based pharmaceuticals (biopharmaceuticals) is more challenging, however, than it is for small-molecule drugs. Rainer Bischoff of the University of Groningen in the Netherlands has been exploring approaches to overcome these challenges. He recently spoke to us about this work.

Click the title above to open The Column December 07, 2016 Europe & Asia issue, Volume 12, Number 22, in an interactive PDF format.

Click the title above to open The Column December 07, 2016 North American issue, Volume 12, Number 22, in an interactive PDF format.

The vast majority of macromolecules exhibit a molar mass distribution that is often described by the polydispersity index (PDI). This Tips & Tricks instalment offers practical advice to consider when analyzing macromolecules using liquid chromatography (LC).

The degree and strength of self-association are critical quality attributes for insulin and its analogues. In this article we present the label-free determination of these quantities using composition-gradient multi-angle light scattering (CG-MALS), enabling the formulation of engineered insulin optimized for stability and efficacy.

A preview of the 8th International Symposium on the Separation and Characterization of Natural and Synthetic Macromolecules (SCM-8).

The ability of size-exclusion chromatography (SEC) to measure critical protein characteristics, such as molecular weight and size, makes the technique valuable from the early stages of novel protein research and development through to formulation and manufacturing support, especially in oligomeric purity and aggregation studies. However, informational output, ease of analysis, and sample requirements all vary considerably depending on whether a system has been truly optimized for protein characterization. This article examines how SEC works and considers how to maximize the productivity, sensitivity, and value of an SEC setup for biopharmaceutical development.

Selected highlights of innovative chromatography products.

This article looks at the practical benefits of microflow liquid chromatography–mass spectrometry (LC–MS) in bioanalysis applications.

This article looks at the practical benefits of microflow liquid chromatography–mass spectrometry (LC–MS) in bioanalysis applications.