LCGC Europe-02-01-2004

LCGC Europe

Comprehensive Two-Dimensional Gas Chromatography

February 01, 2004

GC Connections

17

2

The latest newcomer to the collection of GC techniques, GCXGC, is examined in this instalment. Although this technique is capable of delivering more GC information in a shorter time than other methods, its technical complexity has slowed down widespread acceptance. John Hinshaw explains...

Tissue Sample Preparation — Not the Same Old Grind

February 01, 2004

Sample Preparation Perspectives

17

2

Extracting analytes from biological tissues often presents serious challenges for the analytical chemist. In this column, the guest authors provide an overview of human and animal tissue sample preparation, and compare conventional extraction technologies with novel approaches to these challenges.

Broad Peaks

February 01, 2004

LC Troubleshooting

17

2

Peaks that are too broad can mean that analysts are not using their LC columns very efficiently. In this month's column, John Dolan describes how to determine if peaks are broader than they should be and highlights some of the common system-related causes of peak broadening.

Quo Vadis 21 CFR 11

February 01, 2004

Questions of Quality

17

2

In the welcome return of this column, Bob McDowall revisits the evolving topic of 21 CFR 11 compliance, as it applies to chromatographers. He examines the FDA's activities in 2003 and outlines the current status of its regulations over, and guidance for, electronic records issues.

Analysis of Combinatorial Natural Products by HPLC and CE

February 01, 2004

HPLC and CE

17

2

In this article the authors report on a combinatorial natural product discovery methodology that uses a viral vector system to transfer secondary metabolite-related enzymes from C. roseus to tobacco cell cultures. Using high-resolution separation techniques, including HPLC, CE and MS, they describe the analysis of secondary metabolite patterns.