LCGC Europe-04-01-2004

LCGC Europe

Packed Column Supercritical Fluid Chromatography–Mass Spectrometry for Drug Discovery Applications

April 01, 2004

pSFC?MS

17

4

This article describes the pros and cons of pSFC–MS and attempts to demonstrate its broad applicability to such fields as high-throughput analysis, purity assessment, structure characterization and purification. It concludes with a look at the potential of the technique in the future of analytical drug discovery.

Anatomy of a Peak

April 01, 2004

GC Connections

17

4

This month's column examines the basic measurements of a peak's size and shape for the purposes of assessing and monitoring chromatographic separations over a period of time.

New Chromatography Columns and Accessories at the 2004 Pittcon Conference, Part I

April 01, 2004

Column Watch

17

4

In the first of a two-part series, Ron Majors examines new column introductions at Pittcon with special attention to high performance liquid chromatography columns and packings for reversed-, normal- and bonded-phase; ion exchange; ion and size-exclusion chromatography. He also considers speciality HPLC columns.

Success with Evaporative Light-Scattering Detection, Part II: Tips and Techniques

April 01, 2004

LC Troubleshooting

17

4

Following on from a previous instalment, this month's column assesses evaporative light-scattering detection as a complementary detection mode and builds upon the previous discussion in terms of detector applications.