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LCGC Europe-05-01-2018

LCGC Europe

Practical Approaches to Overcome the Challenges of Comprehensive Two-Dimensional Liquid Chromatography

May 01, 2018

Cover Story

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Comprehensive two-dimensional liquid chromatography (LC×LC) is a powerful technique for separating highly complex samples. However, the proliferation of this technique is hindered by a range of challenges, including the possible impact of the additional separation on the detection sensitivity, concerns that mobile phase incompatibility problems will limit the applicability, and the complexity of the system and associated method development costs. This article addresses these issues and describes how modern modulators and software tools are overcoming the barriers associated with this technique.

Biomimetic Chromatography to Accelerate Drug Discovery: Part 2

May 01, 2018

Features

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The biomimetic gradient retention time measurements on C18, immobilized artificial membrane (IAM), human serum albumin (HSA), and acid-glycoprotein (AGP) stationary phases can be used to characterize compounds partitioning into phospholipids and proteins. The data obtained can then be used in equations to estimate the in vivo plasmaÐtissue distribution of the compounds measured. The plasma protein binding, brain tissue binding, and in vivo drug efficiency can also be calculated using the biomimetic chromatographic data.

A Step-by-Step Guide to Inlet Maintenance

May 01, 2018

The Essentials

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An excerpt from LCGC’s e-learning tutorial on inlet maintenance at CHROMacademy.com

Quantifying Aquatic Toxins Using UHPLC–MS/MS

May 01, 2018

Features

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LCGC Europe spoke to Andrew Turner, Principal Chemist in the Food Safety Group at the Centre for Environment, Fisheries, and Aquaculture Science (Cefas) in Weymouth, UK, about developing a simple ultrahigh-pressure liquid chromatography tandem mass spectrometry (UHPLCÐMS/MS) method for the quantitation of microcystins and nodularin in various sample matrices.

Vol 31 No 5 LCGC Europe May 2018 Regular Issue PDF

May 01, 2018

Issue PDF

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Click the title above to open the LCGC Europe May 2018 regular issue, Vol 31, No 5, in an interactive PDF format.