LCGC North America-01-01-2011

LCGC North America

Making Elephants Fly

January 01, 2011

From the Editor

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When good things are given to us, or when we have never known life without them, we rarely appreciate them fully. This truth applies to many areas of life, but tends to be particularly evident with respect to modern conveniences and technological advances. Anyone with a teenager who thinks having a cell phone or an iPod is a requirement, not a luxury, knows this; pointing out that every generation until this one grew up without such devices rarely elicits more than eye rolling. Young people are not the only ones who take things for granted, however. When was the last time most of us truly felt grateful for our flush toilets or hot showers? Probably shortly after a camping trip or when the water heater broke.

Toward a Universal Detector for Small Molecule Applications: Direct-EI in LC–MS

January 01, 2011

Articles

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This article describes the operating principles of the direct-electron ionization (EI) interface, which is becoming more popular in many LC–MS applications. Matrix effects and the role of direct-EI as a universal detector for small molecule analysis are also discussed in detail. The advantages and drawbacks of this approach are described and a comparison with atmospheric pressure ionization (API) interfaces is made. The potential of direct-EI is illustrated with a selection of practical applications.

Vol 29 No 1 LCGC North America January 2011 Regular Issue PDF

January 01, 2011

Issue PDF

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Click the title above to open the LCGC North America January 2011 regular issue, Vol 29 No 1, in an interactive PDF format.