LCGC North America-01-01-2019

Click the title above to open the LCGC North America January 2019 regular issue in an interactive PDF format.

The challenges we face in troubleshooting problems with liquid chromatography (LC) separations are highly diverse. This month we take a closer look at topics that have garnered more attention recently.

Determining the higher order structure of a protein pharmaceutical is important. Here, we review the approaches for HOS determination that are currently receiving the most attention in the literature and at scientific meetings.

The elution mechanisms for gradient and isocratic HPLC are fundamentally different from each other. Here is what you should understand about both.

By taking simple proactive troubleshooting steps, GC users can ensure that instruments will operate correctly over time, thus avoiding workflow disruptions.

The occurrence of additives like plasticizers in plastic food packaging has been documented, but information on their potential migration into foods is limited. In this pilot study, 2D GC–MS was used to identify chemicals extracted from a common stretch plastic film with a series of organic solvents. In total, 91 compounds were tentatively identified, including five PCBs.

There are many factors to consider in a data integrity and governance program. Fortunately, a simple diagram can help us understand what needs to be covered.