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LCGC North America-05-01-2017
LCGC North America
Statistics for Analysts Who Hate Statistics, Part VI: Derringer Desirability Functions
May 01, 2017
Peer-Reviewed Articles
35
5
Derringer desirability functions are a great favorite of mine because they are very simple and flexible. They may be applied to a variety of problems: whenever you need to select the “best” (sample, method, operating conditions etc.) from a set. It is also a convenient way to compare apples and oranges, whenever totally unrelated features must be ranked. They were first described by Derringer and Markham1 to select polymeric materials based on varied properties.
The Secrets of Successful Gradient Elution
May 01, 2017
The Essentials
35
5
What is required to optimize a gradient elution HPLC method?
Mitigating the Effect of Surfactants in Sample Preparation of a Phospholipid Formulation for Impurities Analysis by Reversed-Phase Liquid Chromatography
May 01, 2017
Peer-Reviewed Articles
35
5
A surfactant based diluent was used in sample preparation for reversed phase HPLC analysis of a drug product and its impurities in a phospholipid formulation. The use of the didodecyl trimethylammonium bromide (DDAB) enabled a consistent, quantitative extraction of the analytes of interest from the lipid matrix in a much more aqueous, weak solvent. Water was added as an anti-solvent to precipitate out the surfactant from the system to eliminate HPLC injection pressure spikes, enabling large volume injections and achieving a consistent, robust method for long term use. Method development and validation steps are described.
Count the Cost, Part III: Increasing Resolution by Changing Selectivity
May 01, 2017
LC Troubleshooting
35
5
Several variables can be used to change selectivity in a liquid chromatographic (LC) separation. Here we compare the variables in an effort to prioritize which experiments will be most effective.
New Sample Preparation Products and Accessories for 2017
May 01, 2017
Sample Prep Perspectives
35
5
This yearly report on new products introduced at Pittcon 2017 (or in the preceding year) covers sample preparation instrumentation, supplies, and accessories.
New Gas Chromatography Products for 2016–2017
May 01, 2017
GC Connections
35
5
Annual review of new developments in the field of GC
Improved Methods for Analyzing Wastewater and Sediments
May 01, 2017
Special Features
35
5
Eric Nelson discusses methods for analyzing halogenated transformation products of pharmaceuticals and other contaminants.
Deirdre Cabooter: LCGC’s 2017 Emerging Leader in Chromatography Award Winner
May 01, 2017
Special Features
35
5
How does the career of a young leader get started?
Pat Sandra: LCGC’s 2017 Lifetime Achievement Award Winner
May 01, 2017
Special Features
35
5
Reflections on a career blending academia and entrepreneurship
Vol 35 No 5 LCGC North America May 2017 Regular Issue PDF
May 01, 2017
Issue PDF
35
5
Click the title above to open the LCGC North America May 2017 regular issue, Vol 35 No 5, in an interactive PDF format.