LCGC North America-06-01-2001

LCGC North America

Determining Specificity in a Regulated Environment

June 01, 2001

Validation Viewpoint

19

6

Krull and Swartz describe how chromatographers can determine peak purity and identity using new software programs.

When Good Columns Go Bad

June 01, 2001

GC Connections

19

6

Hinshaw looks at causes and modes of premature column failure and at practices that ensure the longest possible column life.

Analysis of Weak UV-Absorbing Pharmaceutical Drug Substances Using CE with Condensation Nucleation Light-Scattering Detection

June 01, 2001

Article

19

6

The authors descibe the use of CE with condensation nucleation light-scattering detection to analyze three pharmaceutical analytes. Because the compounds lack adequate UV chromophores, they require a more sensitive means of detection.

Embedded-Polar-Group Bonded Phases for High Performance Liquid Chromatography

June 01, 2001

Featured Article

19

6

The authors compare the chromatographic properties of embedded-carbamate-group bonded phases with those of their purely alkyl counterparts.

High-Speed Analysis of Volatile Organic Compounds in Environmental Samples Using Small-Diameter Capillary Columns and Purge-and-Trap GC–MS Systems

June 01, 2001

Column Watch

19

6

Guest author Cameron George discusses recent advances in purge-and-trap systems that enable considerable reduction in analysis times.

Resin Screening to Optimize Chromatographic Separations

June 01, 2001

Article

19

6

The author presents an approach to screen resins for chromatographic optimization in the purification process of a protein drug substance.

Buffers and Baselines

June 01, 2001

LC Troubleshooting

19

6

This month's "LC Troubleshooting" focuses on the baseline characteristics of several common LC buffers and methods to minimize drift.