LCGC North America-06-01-2001

Krull and Swartz describe how chromatographers can determine peak purity and identity using new software programs.

Hinshaw looks at causes and modes of premature column failure and at practices that ensure the longest possible column life.

The authors descibe the use of CE with condensation nucleation light-scattering detection to analyze three pharmaceutical analytes. Because the compounds lack adequate UV chromophores, they require a more sensitive means of detection.

The authors compare the chromatographic properties of embedded-carbamate-group bonded phases with those of their purely alkyl counterparts.

Guest author Cameron George discusses recent advances in purge-and-trap systems that enable considerable reduction in analysis times.

The author presents an approach to screen resins for chromatographic optimization in the purification process of a protein drug substance.

This month's "LC Troubleshooting" focuses on the baseline characteristics of several common LC buffers and methods to minimize drift.