LCGC-North America-12-01-2020 | LCGC North America

Applying Liquid Chromatography (LC) and Liquid Chromatography–Mass Spectrometry (LC–MS) Methods to the Characterization and Analysis of rAAV

December 01, 2020

Column: Column Watch

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Recombinant adeno-associated viral therapy (rAAV) products are particularly complex. Are liquid chromatography and LC–MS the right tools for their characterization?

A Look at Improved Aroma Profiling of Foods by High-Capacity Sorptive Extraction

December 01, 2020

Focus on Food Analysis

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High-capacity sorptive extraction combined with thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS) can improve on traditional methods for the analysis of VOCs and other trace analytes that contribute to the aroma, flavor, and safety of food products.

An Excerpt from "Optimizing Gas Chromatography Using Column Dimensions"

December 01, 2020

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Judicious initial choices of gas chromatography (GC) column dimensions, and even a change of column dimension during method development, can lead to significant improvements in resolution.

Ionization Efficiency for Environmentally Relevant Compounds Using Atmospheric Pressure Photoionization Versus Electrospray Ionization (ESI)

December 01, 2020

Peer-Reviewed Article

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Atmospheric pressure photoionization (APPI) and electrospray ionization (ESI) are compared for the mass spectrometry (MS) quantitation of pharmaceuticals frequently detected in environmental waters, including antibiotics, beta blockers, and selective-serotonin reuptake inhibitors.

Understanding the Review Process in Ensuring Data Integrity

December 01, 2020

Focus on Data Handling

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A key step in ensuring data integrity is second-person review of data, and data sets must be locked during the review process. Monica Cahilly explains.

Tips for Liquid Chromatography Coupled with Charged Aerosol Detection

December 01, 2020

LC Troubleshooting

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Charged aerosol detection is a powerful complement to UV and MS, but successful implementation requires understanding a few key factors, including response dependencies on temperature, nebulization process, analyte volatility, and mobile-phase composition.