This month's "Directions in Discovery" looks at column and mobile-phase selection as well as system components and modification. Making the right choices among these parameters will help analysts get the most out of their liquid chromatography–mass spectrometry systems.

Tim Wehr is staff scientist at Bio-Rad Laboratories, Hercules, California. Direct correspondence about this column to Direct correspondence about this column to "Directions in Discovery," LCGC, Woodbridge Corporate Plaza, 485 Route 1 South, Building F, First Floor, Iselin, NJ 08830, e-mail lcgcedit@lcgcmag.com.

Configuring HPLC Systems for LC–MS