Drug Screening using GC×GCqMS with Thermal Modulation

March 4, 2011
The Column

Volume 7, Issue 4

In this study, the method of two-dimensional comprehensive GC applying an ultra fast quadrupole mass spectrometer as detector was used (GC×GCqMS).

High separation efficiency is the most important factor in chromatography. All further steps in chromatographic analysis methods for qualitative and quantitative data evaluation depend on it. In particular, effective separation can be achieved through two-dimensional chromatography using different separation mechanisms. In this study, the method of two-dimensional comprehensive gas chromatography (GC) applying an ultra fast quadrupole mass spectrometer as detector was used (GC×GCqMS). New quadrupole MS systems show data acquisition speeds that make them suitable for detection in comprehensive GC.

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