LCGC North America
For many in the world of chromatography and separation science in general, it has been a long 12 months to say the least. With an economic recession gripping the nation and causing secondary effects such as the well-documented "Great Acetonitrile Shortage of 2009," it is easy to see why many readers will not be sorry to see the end of 2009, and why they will be all too happy to welcome in 2010.
For many in the world of chromatography and separation science in general, it has been a long 12 months to say the least. With an economic recession gripping the nation and causing secondary effects such as the well-documented "Great Acetonitrile Shortage of 2009," it is easy to see why many readers will not be sorry to see the end of 2009, and why they will be all too happy to welcome in 2010.
David Walsh
However, the holidays are a time for looking forward with hope and optimism and in this regard, there is much to look forward to, as the market is full of positive indicators for the future. First and foremost, overall demand for instrumentation in the field of separation science is predicted to grow by more than 5% by 2012, while total revenue in the market is predicted to grow by 6% in the same time period, with several market segments seeing high double-digit growth (Strategic Directions International Global Assessment Report, 10th Ed.). Combine these forecasts with some of the more recent developments in the market caused by the acetonitrile shortage, such as the push toward solvent-free instrumentation, smaller-particle-size columns, and more, and the opportunities for growth are plentiful as we move into the New Year.
Finally, on behalf of all of us at LCGC, I would like to take this opportunity to wish all of our readers and their families Happy Holidays and a Happy New Year. This time of year always helps put the focus on the things in life that are most important, and I think we can all agree that economic and market conditions, while vitally important in their place, really do pale in comparison to the joy of celebrating the holidays with family and friends.
Enjoy the holidays.
David Walsh
Editor-in-Chief
The Next Frontier for Mass Spectrometry: Maximizing Ion Utilization
January 20th 2025In this podcast, Daniel DeBord, CTO of MOBILion Systems, describes a new high resolution mass spectrometry approach that promises to increase speed and sensitivity in omics applications. MOBILion recently introduced the PAMAF mode of operation, which stands for parallel accumulation with mobility aligned fragmentation. It substantially increases the fraction of ions used for mass spectrometry analysis by replacing the functionality of the quadrupole with high resolution ion mobility. Listen to learn more about this exciting new development.
The Complexity of Oligonucleotide Separations
January 9th 2025Peter Pellegrinelli, Applications Specialist at Advanced Materials Technology (AMT) explains the complexity of oligonucleotide separations due to the unique chemical properties of these molecules. Issues such as varying length, sequence complexity, and hydrophilic-hydrophobic characteristics make efficient separations difficult. Separation scientists are addressing these challenges by modifying mobile phase compositions, using varying ion-pairing reagents, and exploring alternative separation modes like HILIC and ion-exchange chromatography. Due to these complexities, AMT has introduced the HALO® OLIGO column, which offers high-resolution, fast separations through its innovative Fused-Core® technology and high pH stability. Alongside explaining the new column, Peter looks to the future of these separations and what is next to come.