|Articles|February 1, 2012
- The Column-02-01-2012
- Volume 8
- Issue 2
The Partition Coefficient (log P), Distribution Coefficient (log D) and Acid Dissociation Constant (pKa): Knowing Your Compound for Solid-Phase Extraction Method Development in Reversed-Phase Mode
Author(s)Michael Rummel
Gathering information about the chemical and physical properties of target analytes is an essential step to effective solid-phase extraction (SPE) method development.
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Gathering information about the chemical and physical properties of target analytes is an essential step to effective solid-phase extraction (SPE) method development. Log P, log D and pKa are key analyte characteristics that can have a significant impact on the rapid success of reversed-phase SPE method development. This article explores the value of these chemical properties and demonstrates their importance in efficient reversed-phase SPE method development and optimization.
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