In this month’s column, John Dolan addresses a reader’s peak-splitting problem and suggests ways to avoid such occurrences in the future.
In-Loop Analyte Degradation in Two-Dimensional Liquid Chromatography: Example and Solutions
September 13th 2024In this installment of “LC Troubleshooting,” we describe an artifact that can arise because of compound degradation during the transfer of fractions of the first dimension (1D) column effluent to the 2D separation.