LCGC North America
It seems hard to believe that we are already nearing the holidays and the end of 2009. And for many in the world of separation science, after weathering difficult economic conditions, solvent shortages, and more, welcoming in 2010 will be something to look forward to indeed.
It seems hard to believe that we are already nearing the holidays and the end of 2009. And for many in the world of separation science, after weathering difficult economic conditions, solvent shortages, and more, welcoming in 2010 will be something to look forward to indeed. However, the end of the year can also provide us with a unique perspective and a chance to take stock of the marketplace, and at LCGC, we have done just that.
David Walsh
This month, LCGC presents the results of our most recent HPLC User Survey in Ron Majors' November installment of "Column Watch." In such an eventful year, the results of this survey are more informative — and intriguing — than ever before. For now, we finally have hard data to answer many lingering questions that to this point have been answered largely by consulting popular wisdom and word-of-mouth. Have changes in thinking toward solvent usage changed the overall HPLC market? Which techniques have taken off under these market conditions and which have seen decreases, and most importantly, why? Which column types are being used more than ever, and which types have fallen in popularity? Ron's column answers these questions and more, giving readers their clearest picture yet of where the market stands after the rollercoaster of a year that was 2009.
As always, LCGC strives to bring you the nuts-and-bolts information from the front lines of the separations laboratory, and the 2009 HPLC User Survey is just another example of this commitment. The results presented in this survey come not from revenue projections or informal discussions, rather, they come from having direct interaction with the users performing chromatographic research every day, and we believe this makes them all the more relevant and reliable.
We hope you find this survey and the rest of the industry-leading columns and technical articles in this issue useful, and as usual, feel free to contact us with any comments you may have.
Enjoy the issue.
GC–TOF-MS Finds 250 Volatile Compounds in E-Cigarette Liquids
November 1st 2024A study has used gas chromatography coupled to a time-of-flight mass spectrometer to build an electron ionization mass spectra database of more than 250 chemicals classified as either volatile or semi-volatile compounds. An additional, confirmatory layer of liquid chromatography–mass spectrometry analysis was subsequently performed.
AI and GenAI Applications to Help Optimize Purification and Yield of Antibodies From Plasma
October 31st 2024Deriving antibodies from plasma products involves several steps, typically starting from the collection of plasma and ending with the purification of the desired antibodies. These are: plasma collection; plasma pooling; fractionation; antibody purification; concentration and formulation; quality control; and packaging and storage. This process results in a purified antibody product that can be used for therapeutic purposes, diagnostic tests, or research. Each step is critical to ensure the safety, efficacy, and quality of the final product. Applications of AI/GenAI in many of these steps can significantly help in the optimization of purification and yield of the desired antibodies. Some specific use-cases are: selecting and optimizing plasma units for optimized plasma pooling; GenAI solution for enterprise search on internal knowledge portal; analysing and optimizing production batch profitability, inventory, yields; monitoring production batch key performance indicators for outlier identification; monitoring production equipment to predict maintenance events; and reducing quality control laboratory testing turnaround time.
Multivariate Design of Experiments for Gas Chromatographic Analysis
November 1st 2024Recent advances in green chemistry have made multivariate experimental design popular in sample preparation development. This approach helps reduce the number of measurements and data for evaluation and can be useful for method development in gas chromatography.