Tips & Tricks: GPC/SEC Method Optimization

Paper spray-mass spectrometry vs. liquid chromtography-tandem mass spectrometry (LC-MS/MS): Can rapid screening rival the gold standard in ER drug testing?

Liquid chromatography-tandem mass spectrometry (LC-MS/MS) finds high fentanyl levels do not predict toxicity in tolerant users.

Gas chromatography-ion mobility spectrometry (GC-IMS) identifies odor markers that flag early mold growth in cigar tobacco.

Lorna Nisbet from the Leverhulme Research Centre for Forensic Science, discusses a GC–MS. technique developed to detect anabolic-androgenic steroids in e-cigarettes seized from Scottish prisons.

Kinjal Bhatt and Ina Varfaj trace their pull toward analytical science to a saturated chromatography peak and the moment their first chiral peaks separated.

Gérard Hopfgartner explains why pairing SFC with dopant-assisted APPI can match, or even beat, electrospray sensitivity, even at microflow LC rates.

Emma Macturk from LECO Corporation explains which forensic applications benefit from GC×GC’s greater peak capacity, and when the additional separation power may only provide limited benefits.

Koji Yamaguchi of the International University of Health and Welfare (Narita, Japan) discusses a novel derivatized liquid chromatography-tandem mass spectrometry (LC-MS/MS) method plus propofol glucuronide (PRG) marker which improves forensic propofol detection.