Uncovering Deficiencies in Mass Balance Using HPLC with Chemiluminescence Nitrogen-Specific Detection

Andreas Körner;

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Uncovering Deficiencies in Mass Balance Using HPLC with Chemiluminescence Nitrogen-Specific Detection

April 1, 2002

Andreas Körner

LCGC North America

LCGC North America, LCGC North America-04-01-2002, Volume 20, Issue 4

The author describes using HPLC with chemiluminescence nitrogen-specific detection and aperometric detection to determine organic impurities in a tedisamil dihydrochloride drug substance.