Application Notes: General

Growing trends in oligonucleotide and gene therapy development Commentary on the current global and regional market landscapes The latest methods for the advancement of oligonucleotide and gene therapies and much more!

A polymer-based reversed phase column successfully analyzed ten water-soluble vitamins.

Highly sensitive LC–MS methods for phosphorylated saccharides were demonstrated using simple analytical conditions with Shodex HILICpak VT-50 2D.

This application note demonstrates the performance of Shodex PROTEIN KW-802.5 for the analysis of liraglutide, its monomer and aggregates, as well as phenol in the drug.

This application note demonstrates the performance of multiple Shodex columns for the analysis of antibodies, IgG and Tween.

A polymer-based diol-modified column was used to analyze oligonucleotides.

This study describes the development of an analytical platform based upon TD–GC×GC–TOF-MS and shows its application to the collection and analysis of breath samples.

This application note shows how TD–GC–MS is used to measure volatile organic biomarkers in the breath of individuals with malaria.

This application note describes the BioVOC-2™ breath sampler and its applications, which include clinical diagnostics, occupational health, and public VOC exposure.

This study describes the high-sensitivity screening of disease biomarkers, through use of sampling onto TD tubes, automated preconcentration, and GC×GC–TOF-MS.

Use less solvent, less time, and less operator interaction with a new way to perform a complete fat extraction.

This application note demonstrates the performance of Empore SDB-RPS disks in the monitoring of Organophosphorus pesticides in ground water using EPA Method 8141B.

Read about the advances in pharmaceutical stress testing over the past 20 years, and learn about novel analytical and automation tools that will support your work.

· Traps and “delays” system-related PFAS, preventing interference · Allows accurate identification and quantitation of trace-level PFAS · Highly retentive-no breakthrough even with extended equilibration times

-Analysis of the Fast-5 pesticides -New directions in terpenes testing -FAQs about pesticides analysis in cannabis testing

- Solid-phase extraction can now enable robust extraction and solid results. - SPE cartridge technology provides advantages for extracting water samples.

Why water quality matters Improved weighing accuracy that conforms to regulations How filtration impacts your HPLC results

H2O2 is often used as oxidizing agent in toothpaste. A fast and sensitive method is presented to allow the quantitation of hydrogen peroxide in less than 3 min.

This note using YMC-Triart Bio C4 shows a robust separation at high temperatures for three commercially available mAbs: ofatumumab, palivizumab, and panitumumab.

This application note demonstrates the performance of an IC-MS/MS workflow for the analysis of polar pesticides in compliance with EU MRLs and EU SANTE guidelines.

This application note presents the role of ultrapure water in HPLC analysis.

This application note demonstrates the use of high-temperature headspace sampling as a surrogate vaporization environment to evaluate e-juice thermal degradation.

* Novel balance systems: next step toward lab automation? * Trends in sample prep * New lab weighing technology

-Use of smaller and sub-2-µm superficially porous particles for LC separations -Adoption of LC and SPP in cannabis testing -Metal–organic frameworks for liquid chromatography

The Column spoke to Jelle De Vos from the Department of Chemical Engineering at the Vrije Universiteit, in Brussels, Belgium, about his work investigating the performance of columns packed with 1.7-μm particles at high-pressure conditions (ΔPmax = 1034 bar) and linking it to particle and column-bed integrity.

A review of the 13th International Symposium on Packed Column SFC and SFE Techniques (SFC 2019), which was held in Philadelphia, Pennsylvania, USA, on 29 September–1 October 2019.

-483 citations and data integrity -FDA’s Data Integrity Guidance -Weighing in pharmaceutical and food labs