Application Notes: General

In reversed-phase liquid chromatography, increasing the column temperature usually results in a decrease in analyte retention. Will this cause problems if a method does not call for control of the column temperature but the room temperature of the laboratory environment changes?

“GC Connections” presents the column’s annual review of new developments in the field of gas chromatography seen at Pittcon and other venues in the past 12 months.

More and more manufacturers are embracing multi-attribute method, which simplifies biopharmaceutical product quality testing, and facilitates the measurement and monitoring of critical quality attributes.

An HCP analysis workflow including the Agilent AssayMAP Bravo platform for automated sample preparation, 6545XT AdvanceBio LC/Q‑TOF for LC-MS/MS analysis

This whitepaper demonstrates the features and benefits of owning an Ultivo LC/TQ in terms of actual tangible benefits to your laboratory operations.

A method describing the detection of 12 potentially mutagenic nitrosamine impurities found in sartan drugs using the Ultivo LC/TQ

FFF-MALS-DLS provides the detailed characterization of nano-pharmaceuticals that is essential for development and regulatory filing.

Stay one step ahead of water regulation, QSight™ LC–MS/MS offers sensitivity, selectivity, and robustness while saving time on maintenance and cleaning operations for your testing.

This application demonstrates the efficacy of this chromatographic technique for a fast orthogonal analysis to evaluate mAb ADCC activity.

The Zebron ZB-PAH-EU and ZB-PAH-SeleCT offer unparalleled performance of targeted selectivity for PAHs in food, environmental, electronics, and fuel industries.

In this application, we look at purgeable volatile organic compounds by GC–MS using Zebron™ ZB-624PLUS™ GC columns.

In this application, we look at residual solvents per USP 467 using Zebron™ ZB-624PLUS™ and ZB-WAXPLUS™ GC columns.

How to reduce FAME run times by up to 75% and improve the separation of cis/trans FAME isomers while remaining compatible with AOAC, AOCS, and IOC regulatory methods.

In this application, we look at the fast analysis of alcohol-based sanitizers by GC–FID using Zebron™ ZB-WAXPLUS™ GC columns.

ZB-WAXplus offers performance nothing short of extraordinary – from 100 % aqueous stability to exceptional inertness.

Inert GC inlet liners for sample protection are easy to install. Touchless packaging provides protection from cuts or breakage, reducing contamination during installation process.

We look at the fast and accurate GC–MS analysis of polycyclic aromatic hydrocarbon (PAHs) in rubber and plastic using a Zebron™ ZB-PAH-EU GC column.

The ZB-DHA-PONA GC column has excellent response and peak symmetry for polar oxygenates - for DHA, PONA, PIONA, PIANO, ASTM methods (D5134, D5441, D5501, D6729, D6730, D6733).

We look at the Zebron ZB-624plus, the optimal choice for the analysis of volatile compounds for environmental, pharmaceutical, food, cannabis, and specialty chemicals.

In this application, we look at the determination of residual solvents and terpenes in cannabis by GC–FID using the Zebron™ ZB-624plus™ GC column.

With Antec Scientific’s new ground-breaking µ-PrepCell-SS, electrochemical reduction of disulfide bonds in peptides, proteins, mAbs, and other biopharmaceuticals becomes possible routinely in LC-MS workflows. • Fast and efficient reduction of S-S bonds • Robust on-line reduction in top-down and bottom-up Proteomics • Reagent free, no interfering DTT or TCEP, ideal for HDXMS • Superior peptide sequencing and S-S bond assignment

Erythromycin analysis in creams, lotions, etc., based on HPAEC-PAD using the ALEXYS Antibiotics Analyzer according to the official 2018 USP 41-NF36 monograph.

HPAEC-PAD with a 4-step potential waveform is applied for analysis of Erythritol, Xylitol, Sorbitol, Mannitol, and Maltitol, resulting in excellent reproducibility.

Fast and sensitive analysis of plant sterols and plant stanols, using electrochemically detection without derivatization on Boron-Doped Diamond (BDD) electrodes.

For the analysis of iodide in milk a sensitive and robust HPLC-ECD method is presented, using a Boron Doped Diamond (BDD) working electrode for detection.

The ALEXYS Antibiotics Analyzer is used for routine assay and impurity analysis of Azithromycin in various formulations according USP 41 monographs.

The use of the ALEXYS Neurotransmitter Analyzer is shown for sensitive analysis of the neurotoxin 3-HK down to a detection limit of 0.4 nM.