Application Notes: General

*The challenges of temporary data *How dynamic data auditing helps compliance with data integrity standards *What to look for in a LIMS platform for 21 CFR Part 11 and Annex 11 compliance

Using Full Evaporation Technique (FET) to analyze the solvent residual (California Residual Solvents Category I and II) in cannabis oil by a CDS dynamic headspace module

- A data life cycle for chromatography - What is GDocP? - Understanding data integrity metrics for chromatography

Essential oils have been a staple of the food, fragrance, and health markets for many years. Owing to their unique composition, essential oils can be used for a variety of applications.

This application note showcases the development of two methods using photodiode array detection (PDA) to separate three isomers of tocopherol (vitamin E).

What you will learn: - New workflow aims to ameliorate the difficulties of water analysis - Incorporates risk assessments/cheminformatics to prioritize suspect chemicals - Strategy increases confidence in the results.

What you will learn: - Automated extraction method achieves higher recoveries - Steps involved in QuEChERs vs. EDGE method

-Automated SIFT–MS increases productivity for thermal desorption tube analysis. -Case studies show that TD–SIFT–MS improves analysis for several applications.

Pickering Laboratories developed an easy and sensitive method to analyze aflatoxins B1, B2, G1, G2, and ochratoxin A in hemp and hemp-containing edible products. Mycotoxins are isolated using immunoaffinity clean-up columns and analyzed with fluorescence detection. To increase sensitivity of aflatoxins B1 and G1, an in-line photochemical reactor (UVETM) is installed before the detector. This method utilizes standard HPLC equipment and allows laboratories to easily determine these mycotoxins at low ppb levels.

-Overview of international guidances for data integrity -Insight into PIC/S guidances -Challenges of managing documentation

• Solutions for comparing innovator and biosimilar mAbs • Biosimilar case studies

• Data security in electronic versus paper environments • Division of responsibilities between users and vendors • Specific payment plans can provide advantages to meet financial goals.

Automated QuEChERS clean-up of hemp oil extracts combined with liquid introduction and PTV-GC–MS determination of pesticides leads to improved throughput and low LOQs.

This application note adopted the Full Evaporation Technique (FET) to analyze the solvent residual, based on California Residual Solvents Category, in cannabis oil.

The ability to predict multiple constituents of a final dosage form in one fast, nondestructive measurement can reduce analysis time and cost significantly.

• Acquiring laboratory equipment raises a number of challenges and concerns. • Specific payment plans can provide advantages to meet financial goals.