Using ultra high-performance liquid chromatography-quadrupole time-of-flight tandem mass spectrometry (UHPLC-QTOF-MS/MS), researchers characterized pressurized liquid extracts of artichoke by-products and identified a diverse range of phenolic and flavonoid compounds, including caffeoylquinic acid derivatives, obtained through a greener extraction approach.
LCGC International spoke to David Bishop of the University of Technology Sydney about a new ruthenium-based tyramide amplification tag that combines fluorescence imaging with mass spectrometry imaging to improve detection and quantification of low-abundance proteins in tissue samples.
The week’s highlights include a four-part interview with Koen Vanhoutte of Johnson & Johnson Innovative Medicine on building more sustainable and efficient analytical laboratories, alongside stories on self-optimizing LC workflows, chromatography-based orange juice debittering, pesticide transformation during apple digestion, LC–MS/MS vitamin D profiling in breast cancer patients, and approaches for monitoring microbial spoilage in refrigerated meat.
Gas chromatography-mass spectrometry (GC-MS) and high-performance liquid chromatography (HPLC) analyses demonstrate that walnut septum extracts exhibit habitat-dependent compositional variability in amino acids and phenolics, which correlates with differences in antimicrobial activity against Gram-positive and Gram-negative bacteria.
Advanced gas chromatography analysis reveals that palladium-based catalysts effectively reduce chlorine in polyvinyl chloride (PVC)-derived pyrolysis oil, improving its suitability for cleaner fuel applications.
An optimized ultrahigh-performance liquid chromatography-tandem mass spectrometry (UHPLC–MS/MS) method with tailored sample preparation enables accurate simultaneous detection of 30 PFAS compounds in seawater, sediment, and suspended particles, revealing their distribution and variability across marine environments.
Gas chromatography (GC) of collected surgical emissions shows that a simple closed-circuit transurethral resection (TUR) system can reduce exposure to harmful smoke compounds during prostate surgery.
Using headspace-gas chromatography-ion mobility spectrometry (HS-GC-IMS) and solid phase microextraction-GC-mass spectrometry (SPME-GC-MS) coupled with multivariate modelling, researchers correlated meat volatile profiles with microbial counts to enable rapid, chromatography-based assessment of spoilage and shelf-life.
Researchers used liquid chromatography–mass spectrometry (LC–MS) to analyze hormone profiles in elite athletes, finding that some athletes with XY differences in sex development (DSD) showed testosterone patterns more similar to male athletes, helping improve understanding of conditions such as androgen insensitivity syndrome and 5α-reductase type 2 deficiency in competitive sports.
Using chromatography–mass spectrometry with ultrasound- and enzyme-based extraction methods, researchers showed that selenium speciation and recovery in broccoli sprouts depend on the extraction approach, providing insight into plant selenium uptake and metabolism relevant to food biofortification.
Using liquid chromatography-tandem mass spectrometry (LC–MS/MS) to measure pre-treatment vitamin D levels, researchers found that low vitamin D is associated with a higher risk of severe paclitaxel-induced nerve damage in breast cancer patients.
Using high-performance liquid chromatography-mass spectrometry (HPLC–MS) alongside bioassays and microbiota analysis, research has shown that gastrointestinal digestion alters the chemical fate, bioaccessibility, and toxicity of pesticides in apples in a compound-dependent manner.
A chromatography-based, non-heat process removes bitterness from orange juice while preserving its flavor and nutrients. LCGC International spoke to Araceli Rivera‑Pérez, lead author of the paper that resulted from its development.
Using thermal desorption–gas chromatography–mass spectrometry (TD–GC–MS), researchers identified hundreds of wildfire smoke chemicals trapped in firefighter respirator filters and carbon cartridges, including several toxic compounds, highlighting the need for improved respiratory protection design.
Recent highlights in chromatography and mass spectrometry showcased advances in environmental monitoring, biomedical analysis, materials testing, textile safety, planetary science, and scientific communication, demonstrating the expanding impact of LC–MS and GC–MS technologies across research fields.
Rapid liquid chromatography-tandem mass spectrometry (LC-MS/MS) analysis of wastewater samples across England revealed widespread and fluctuating community drug use patterns—particularly high cocaine and ketamine levels—highlighting the power of chromatography-based methods for real-time public health monitoring.
High-performance liquid chromatography (HPLC) analysis showed that the peel of the citrus fruit bushukan contains low levels of key flavonoids, highlighting that presumed health benefits of citrus peels should be confirmed through species-specific chemical testing rather than assumed from fruit type.
Using targeted liquid chromatography–tandem mass spectrometry (LC-MS/MS), researchers showed that many sphingolipid levels rise with age and differ between men and women, highlighting the need for age- and sex-specific reference ranges before these markers can be used in routine health risk assessment.
Gas chromatography–mass spectrometry (GC-MS) revealed that a stepwise precooling method better preserves key flavor-related aldehydes and esters in cherry tomatoes compared to conventional single-step cooling, helping maintain aroma quality during storage.
Using liquid chromatography-tandem mass spectrometry (LC-MS/MS), researchers mapped where sugar-related collagen crosslinks occur in human bone and found site-specific differences in their distribution and only weak links to bone strength.
Using gas chromatography-mass spectrometry (GC-MS) and liquid chromatography-mass spectrometry (LC-MS) alongside sensory tools, researchers showed that different cooking methods systematically alter the chemical compounds—and therefore the flavor profile—of Yuxiang shredded pork.
Using gas chromatography–mass spectrometry (GC–MS), researchers showed that low, non-lethal exposure to deltamethrin alters key fatty acids in honey bee brains, indicating disrupted neural metabolism that may underlie pesticide-related cognitive effects.
A recent study developed and validated a highly sensitive reversed-phase high-performance liquid chromatography (RP-HPLC) fluorescence method using OPA/ethanethiol derivatization to simultaneously quantify multiple gentamicin C-subtypes in tiny murine perilymph samples, enabling improved pharmacokinetic analysis in the inner ear. LCGC International spoke to Shreshtha Dash and Peter Streyger, two of the authors of the paper that resulted from this study,1 about their work.
Using gas chromatography–mass spectrometry (GC-MS) aboard the Curiosity rover, scientists have identified more than 20 organic compounds in ancient rocks from Gale Crater, revealing a diverse mix of carbon-based molecules and helping advance the search for the origin—and possible biological significance—of organic matter on Mars.
From a preview of HTC-19 in Leuven to cutting-edge insights from analytica 2026, this week’s highlights span breakthroughs in environmental screening, non-invasive diagnostics, green analytical methods, and emerging biomarkers for adolescent mental health.
Liquid chromatography-tandem mass spectrometry (LC–MS/MS) hair analysis combined with surveys at a Portuguese music festival revealed frequent drug use, discrepancies with self-reports, and widespread polydrug exposure, demonstrating chromatography’s value for objective, long-term substance use assessment in high-risk settings.
Using liquid chromatography-mass spectrometry (LC-MS)-based metabolomics and lipidomics, researchers identified obesity-linked biomarkers, highlighting hexanoylglycine and LPC (16:0) as potential causal indicators tied to immune pathways and cardiometabolic risk.
Researchers used high-performance liquid chromatography (HPLC) to identify how 19 breast milk sugars shape healthy gut bacteria in 500 infants, discovering age-specific impacts that persist even after breastfeeding ends.
Ultra-performance liquid chromatography–high-resolution mass spectrometry (UPLC-HRMS) was used to profile metabolomic changes during papain- and bromelain-mediated hydrolysis of gourami fish proteins. Distinct time- and enzyme-dependent profiles revealed differences in proteolysis and metabolite release, highlighting strategies to optimize bioactive peptide production and enhance the nutritional functionality of fish-derived food products.
Researchers used gas chromatography-mass spectrometry (GC-MS) and chemometric analysis to identify 54 metabolites in commercial lavender oils, identifying quality markers like linalool and detecting potential adulteration with synthetic additives.
