This special article series highlights the work of young analytical chemists.

The Next Generation

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Articles

With suspect PFAS screening becoming more popular, and the list of known PFAS now in the thousands, novel analytical tools are needed to generate transferable data sets. We highlight key updates here.

Tools for Investigating the Expanding Per- and Polyfluoroalkyl Substances (PFAS) Universe

When should multidimensional GC approaches be used for analyzing complex samples and analytes?

Multidimensional Gas Chromatography: Benefits and Considerations for Current and Prospective Users

Better sample preparation and miniaturized separations are enhancing these analyses.

Development of Highly Sensitive LC–MS and CE–MS Methods for In-Depth Proteomic and Glycomic Profiling of Limited Biological Samples

New sample preparation workflows for intact proteins in biological matrices are needed. We hope that others will join in this important field of research.

The Crucial Step in Every Analytical Workflow: Sample Preparation—Are We Ready For a Growing Area of Intact Protein Analysis?

Advances in sample preparation have enabled analysis of RNA modifications in single cells, paving the way to discovering new insights into the functions of these molecules.

Sample Preparation Strategies for Characterizing RNA Modifications in Small-Volume Samples and Single Cells

Multidimensional liquid chromatography (MDLC) methods have revolutionized the characterization of complex drug modalities like antibodies–drug conjugates, antisense oligonucleotides, and small interfering RNA therapeutics.

Cracking the Code of Complex Drug Modalities via Multidimensional Liquid Chromatography Coupled to Mass Spectrometry

Two-dimensional LC, with advanced modulation techniques, can advance the analysis of advanced polymeric materials, assisting in characterizing copolymer composition heterogeneity and identifying ingredients in complex products.

Gaining New Insights in Advanced Polymeric Materials Using Comprehensive Two-Dimensional Liquid Chromatography

Examples from food science illustrate the usefulness of chemometrics techniques like pattern recognition, regression, and classification.

Enter the Matrix: Improving the Interpretation of Separations Data Using Chemometrics in Analytical Investigations

HPLC is emerging as the preferred analytical method for potency testing of cannabinoids, but fundamental work is needed to solve critical issues and contribute to advancing knowledge.

Perspectives and Pitfalls in Potency Testing of Cannabinoids by High Performance Liquid Chromatography (HPLC)

Compact instrumentation offers important advantages for many workflows, as illustrated by these examples.

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