American Society for Mass Spectrometry (ASMS)

Wallman unpacks how graph-level fragmentation in fragDETR captures internal fragments and neutral losses, with peak and intensity improvements concentrated in challenging non-standard peptides.

Wallman explains how spectral library accuracy, retention time prediction, and instrument-specific variation make deep learning essential yet difficult in data-independent acquisition proteomics.

Wallman details PeptDeepKontext, a model built to predict peptide properties across diverse instruments and PTMs by embracing rather than eliminating inter-laboratory variability.

Exact mass, isotopic distribution, and MS/MS library matching are used together to differentiate PFAS hits from sulfur-rich food compounds that share a similar mass defect range.

Antonio Ferracane addresses regulator concerns about cleanup-free PAH methods, noting cleanup isn't mandatory if matrix validation proves reliable.

The approach remains non-targeted by prioritizing PFAS-like ions in the first DDA pass; the tunable mass tolerance window can be adjusted to capture structurally unusual PFAS subclasses.

Christine Fisher describes her method using mass defect filtering at the data acquisition stage to improve non-targeted PFAS detection in complex food matrices.

Antonio Ferracane explains how each sample prep step adds error and can strip target PAHs, so skipping cleanup can improve recovery, accuracy, and precision.

Antonio Ferracane discusses moving to minimal sample preparation for PAH analysis, and why matrix-matched calibration can replace cleanup steps.

Antonio Ferracane outlines a combined technique using cryogenic peak compression and pseudo-MRM to sharply boost sensitivity for trace PAHs.

ASMS 2026 highlighted AI-driven MS software, faster/deeper proteomics, spatial biology imaging, biopharma characterization tools, PFAS monitoring, and greener instrumentation.

2026 ASMS awards honor advances in native MS, single-cell proteomics, metabolomics, and instrumentation, spotlighting mass spectrometry's scientific impact.

ASMS 2026 highlights a potential paradigm shift in metabolomics, as new evidence suggests many unknown signals are ESI artifacts.

During ASMS 2025, LCGC International covered the most notable news from corporate and individual attendees, highlighting the latest advancements in mass spectrometry.

In the final moments of our time with Tian (Autumn) Qiu, winner of the ASMS 2025 Research Award, she discusses what initially drew her to the conference and what makes her enjoy returning.

In the fourth section of our time with Tian (Autumn) Qiu, winner of the ASMS 2025 Research Award, she discusses the mentors who guided her to where she is now and imparts advice to future mass spectrometrists.

In the third section of our time with Tian (Autumn) Qiu, she discusses how mass spectrometry can be useful in environmental toxicology research.

In the food industry, evolving consumer demands, contamination concerns, and workforce issues are driving significant changes in food analysis and instrumentation.

In the second part of our time with Tian (Autumn) Qiu, she discusses her laboratory research into the interactions between hosts and microbes, with mass spectrometry techniques being useful in these efforts.

In the first part of our time with Tian (Autumn) Qiu, she shares her thoughts on winning the ASMS 2025 Research Award.

At the 2025 ASMS conference, YongDong Wang, co-founder and CEO of Cerno, emphasized the critical importance of high-quality, calibrated data as the foundation for effective AI and machine learning applications in mass spectrometry, while advising young chemists to master fundamentals alongside emerging technologies.

Here is some of the most popular content posted on LCGC International this week.

At the ASMS Conference in Baltimore, the company highlighted several new products tailored to a range of application areas, including biopharmaceutical development and environmental analysis.

Cerno Bioscience develops vendor-neutral software to streamline mass spectrometry spectral analysis, partnering with major manufacturers like Agilent and Thermo Fisher Scientific while expanding into new global markets.

At this year’s ASMS conference, LCGC interviewed executives from leading analytical science and technology companies to explore emerging trends and gain professional insights. During these discussions, they focused on key advice for early-career analytical chemists to prioritize in today’s evolving field.

At the ASMS 2025 conference, Sciex showcased its latest mass spectrometry system, the ZenoTOF 8600, along with updates to its software platform designed to enhance data processing and analysis for complex workflows.

Thermo Fisher Scientific launched two advanced mass spectrometers and emphasized its multi-omics strategy during the American Society for Mass Spectrometry (ASMS) conference in Baltimore, Maryland this week.

At the ASMS conference, Jack Henion emphasized contributions from colleagues and industry partners. He reflected on innovations that have shaped liquid chromatography–mass spectrometry (LC–MS) and the importance of teamwork in driving scientific breakthroughs.

Jonah Kirkwood, Agilent’s chief commercial officer, emphasized the company’s focus on high-growth markets and its dedication to partnering closely with customers to address their changing needs.

In the final moments of our time with Varun Gadkari, he shares advice for the next generation of mass spectrometrists.