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The Application Notebook-12-01-2008

The Application Notebook

GC–MS Screening for Melamine Adulteration in Baby Formula and Dairy Products

December 02, 2008

Food and Beverage

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Melamine is an industrial chemical with a high nitrogen content that can cause kidney stones and lead to renal failure. In some instances, melamine has been added to baby formula and dairy products as a substitute for protein. This paper presents an efficient and definitive gas chromatography–mass spectrometry (GC–MS) method to identify melamine and related compounds based on the released US Food and Drug Administration (FDA) method.

Analysis of PCBs in Food and Biological Samples Using GC-Triple Quadrupole MS–MS

December 02, 2008

Food and Beverage

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This application details a fast, reliable and highly selective trace-level screening method for the quantification of polychlorinated biphenyls (PCBs) in environmental, food and biological samples, using gas chromatography and a triple stage quadrupole mass spectrometer. The analytical strategy is analogous to the well-established US Environmental Protection Agency (USEPA) Method 1668A.

A Highly Sensitive Method for the Analysis of Tamsulosin (Flomax) in Human Plasma

December 02, 2008

Medical/Biological

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A highly sensitive analytical method for the analysis of tamsulosin in human plasma has been developed for use in bioanalytical studies. The solid-phase extraction (SPE) and UPLC–MS–MS methodologies are described, as well as performance against validation parameters.

maXis High Resolution LC–MS Makes the Most of Ultrafast LC Separations

December 02, 2008

General

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An ultrafast gradient LC separation method was developed to separate a 5-component drug mixture in 30 seconds, with peak widths of 1 second. maXis mass accuracy at sub-ppm levels and true isotopic pattern of the spectra from the peaks lead to a confident elemental formula assignment for each drug compound with the SmartFormula algorithm.