The Column
November 06, 2019
Cover Story
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The Column spoke to Nelson Roberto Antoniosi Filho, a professor at the Chemistry Institute of the Federal University of Goiás (UFG), in Goiânia, Brazil, about his development of a gas chromatography–mass spectrometry (GC–MS) method for cancer diagnosis using cerumen.
November 06, 2019
News
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Agilent Technologies has announced the opening of a new state-of-the-art facility for spectroscopy research and development at the Harwell Science and Innovation Campus in Oxfordshire, UK.
November 06, 2019
News
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SepSolve Analytical Ltd has opened a state‑of‑the-art laboratory and training facility in Waterloo, Canada, to improve its service to North American customers.
November 06, 2019
News
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Researchers attempting to overcome complex matrix interference in commercial food analysis have developed a targeted LC–MS/MS method and open source analysis software capable of identifying allergens in complex food matrices.
November 06, 2019
News
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Sartorius Stedim Biotech (SSB) has agreed to acquire parts of Danaher’s Life Science portfolio.
November 06, 2019
News
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Researchers have developed two new methods for the analysis of MOAHs in highly purified mineral oil fractions (white oils) using comprehensive AgLC×GC, one method uses FID, while the other uses VUV.
November 06, 2019
Features
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HTC-16 will be held from 29–31 January 2020 in Ghent, Belgium. This event preview offers a sneak peak of what to expect.
November 06, 2019
Features
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The utility of native high-resolution mass spectrometry (HRMS) in intact protein characterization is rapidly growing because of advances in both ion-exchange chromatography (IEC) as well as MS-compatible buffer systems. MS is a critical component of biotherapeutic characterization, but its combination with traditional chromatographic separations, such as size-exclusion chromatography (SEC) and IEC, has been slow because of the predominant use of high salt mobile phases, which are incompatible with MS. Recently reported methods using cation-exchange chromatography (CEX) with volatile buffer systems for pH gradient elution has given researchers the ability to use these chromatographic techniques with MS detection. In this article a robust, MS-compatible buffer system for high sensitivity IEC with pH gradient elution for charge variant analysis of intact monoclonal antibodies (mAbs) is described.
November 06, 2019
Features
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Kevin Schug delves into modern microscale liquid chromatography (LC) stationary phases.
November 06, 2019
Features
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Glycosylation is the most common monoclonal antibody (mAb) post‑translational modification. What is essential to know about it?
November 04, 2019
Issue PDF
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Click the title above to open The Column November 2019 North American issue, Volume 15, Number 11, in an interactive PDF format.
November 04, 2019
Issue PDF
15
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Click the title above to open The Column November 2019 Europe & Asia issue, Volume 15, Number 11, in an interactive PDF format.