The Column-11-06-2019

The Column

Diagnosing Cancer Using Cerumen and HSGC–MS

November 06, 2019

Cover Story

15

11

The Column spoke to Nelson Roberto Antoniosi Filho, a professor at the Chemistry Institute of the Federal University of Goiás (UFG), in Goiânia, Brazil, about his development of a gas chromatography–mass spectrometry (GC–MS) method for cancer diagnosis using cerumen.

Agilent Opens New UK Spec Facility

November 06, 2019

News

15

11

Agilent Technologies has announced the opening of a new state-of-the-art facility for spectroscopy research and development at the Harwell Science and Innovation Campus in Oxfordshire, UK.

SepSolve Analytical Unveils New Canadian Facility

November 06, 2019

News

15

11

SepSolve Analytical Ltd has opened a state‑of‑the-art laboratory and training facility in Waterloo, Canada, to improve its service to North American customers.

Challenging Allergen Uncertainty Using LC–MS/MS

November 06, 2019

News

15

11

Researchers attempting to overcome complex matrix interference in commercial food analysis have developed a targeted LC–MS/MS method and open source analysis software capable of identifying allergens in complex food matrices.

Sartorius Announces Acquisition of Danaher Life Science Portfolio

November 06, 2019

News

15

11

Sartorius Stedim Biotech (SSB) has agreed to acquire parts of Danaher’s Life Science portfolio.

Analysis of White Oils Using AgLC×GC

November 06, 2019

News

15

11

Researchers have developed two new methods for the analysis of MOAHs in highly purified mineral oil fractions (white oils) using comprehensive AgLC×GC, one method uses FID, while the other uses VUV.

High Sensitivity Native Mass Spectrometry with Cation Exchange Chromatography

November 06, 2019

Features

15

11

The utility of native high-resolution mass spectrometry (HRMS) in intact protein characterization is rapidly growing because of advances in both ion-exchange chromatography (IEC) as well as MS-compatible buffer systems. MS is a critical component of biotherapeutic characterization, but its combination with traditional chromatographic separations, such as size-exclusion chromatography (SEC) and IEC, has been slow because of the predominant use of high salt mobile phases, which are incompatible with MS. Recently reported methods using cation-exchange chromatography (CEX) with volatile buffer systems for pH gradient elution has given researchers the ability to use these chromatographic techniques with MS detection. In this article a robust, MS-compatible buffer system for high sensitivity IEC with pH gradient elution for charge variant analysis of intact monoclonal antibodies (mAbs) is described.

Vol 15 No 11 The Column November 2019 North American PDF

November 04, 2019

Issue PDF

15

11

Click the title above to open The Column November 2019 North American issue, Volume 15, Number 11, in an interactive PDF format.

Vol 15 No 11 The Column November 2019 Europe & Asia PDF

November 04, 2019

Issue PDF

15

11

Click the title above to open The Column November 2019 Europe & Asia issue, Volume 15, Number 11, in an interactive PDF format.