LCGC Europe-05-01-2005

LCGC Europe

The Bermuda Triangle

May 01, 2005

LC Troubleshooting

18

5

This month, John Dolan turns his attention to the unexplained forces that seem to inhabit laboratories in spite of the most ardent troubleshooting efforts.

Preparative Chiral SFC as a Green Technology for Rapid Access to Enantiopurity in Pharmaceutical Process Research

May 01, 2005

Column Watch

18

5

This month’s column provides an overview of green chemistry issues relating to preparative chiral SFC chromatography in support of preclinical development in the pharmaceutical industry.

A Question of Time (and Date)

May 01, 2005

Questions of Quality

18

5

Bob McDowall stresses the importance of using accurate and precise time and date stamps to ensure the integrity of the data and results generated by computerized systems in any chromatography laboratory.

What’s in a Method

May 01, 2005

GC Connections

18

5

John Hinshaw asks what constitutes a chromatographic method and addresses some of the issues that method transfer raises for method documentation and validation.

PeakMaster — A Freeware Simulator of Capillary Zone Electrophoresis

May 01, 2005

CE Currents

18

5

The authors describe how this free downloadable software calculates and displays CZE separations after the user has entered sample and operations parameters. The underlying principles and mathematical basis are explained.

Choice of Buffer for the Analysis of Basic Peptides in Reversed-Phase HPLC

May 01, 2005

Buffer Choice

18

5

This article examines the results of chromatographic performance when using different buffers. A study of the origins of the differences in peak shape obtained when using varying buffers–additives is presented with regard to the analysis of basic peptides in reversed-phase HPLC.